Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis
Abstract
The combination of alteplase, a recombinant tissue plasminogen activator, and edaravone, an antioxidant, reportedly enhances recanalization after acute ischemic stroke. We examined the influence of edaravone on the thrombolytic efficacy of alteplase by measuring thrombolysis using a newly developed microchip-based flow-chamber assay. Rat models of embolic cerebral ischemia were treated with either alteplase or alteplase-edaravone combination...
Paper Details
Title
Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis
Published Date
Jan 1, 2017
Volume
2017
Pages
1 - 14
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