Review paper
Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
Abstract
PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the development of therapeutic PCSK9-inhibition. However, there is limited evidence that PCSK9 variants are associated with ischaemic stroke (IS). Associations of the loss-of-function PCSK9 genetic variant (rs11591147; R46L), and five additional PCSK9 variants, with IS and IS subtypes (cardioembolic, large...
Paper Details
Title
Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke
Published Date
Jul 17, 2017
Journal
Volume
39
Issue
5
Pages
354 - 359
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