scinapse is loading now...
Rory Collins
Clinical Trial Service Unit
545Publications
131H-index
128kCitations
Publications 545
Newest
Published on May 24, 2019in International Journal of Cancer 7.36
Lu Wang (Nanjing Medical University), Guangfu Jin35
Estimated H-index: 35
(Nanjing Medical University)
+ 173 AuthorsFeng Chen (Nanjing Medical University)
Source Cite
Published on May 1, 2019in The Lancet 53.25
Iona Y. Millwood15
Estimated H-index: 15
(Medical Research Council),
Robin G Walters1
Estimated H-index: 1
(Medical Research Council)
+ 18 AuthorsRuying Hu10
Estimated H-index: 10
(Centers for Disease Control and Prevention)
Summary Background Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect alcohol drinking patterns. We used these two variants to assess the relationships between cardiovascular risk and genotype-predicted mean alcohol intake in men, contrasting the findings in men with those...
1 Citations Source Cite
Published on Apr 7, 2019in European Heart Journal 23.43
Thomas J. Littlejohns8
Estimated H-index: 8
(Clinical Trial Service Unit),
C. Sudlow45
Estimated H-index: 45
(University of Edinburgh)
+ 1 AuthorsRory Collins131
Estimated H-index: 131
(Clinical Trial Service Unit)
Cardiovascular disease and its associated risk factors, such as hypertension and high cholesterol, are major contributors towards global morbidity and mortality. Epidemiological studies provide the scientific evidence base to develop effective preventive strategies and treatments for cardiovascular disease. However, previous cohorts have been restricted by small sample sizes and/or a lack of diverse outcomes, thereby limiting the identification of small, but clinically relevant, associations as ...
12 Citations Source Cite
Published on Apr 1, 2019in Nature Medicine 32.62
L Sun1
Estimated H-index: 1
(Clinical Trial Service Unit),
Robert Clarke109
Estimated H-index: 109
(Clinical Trial Service Unit)
+ 14 AuthorsYiping Chen24
Estimated H-index: 24
(University of Oxford)
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than in Western populations3–5, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of ...
1 Citations Source Cite
Published on Mar 11, 2019in Kidney International 8.43
Iryna Schlackow8
Estimated H-index: 8
,
Borislava Mihaylova16
Estimated H-index: 16
+ 8 AuthorsAlastair Gray64
Estimated H-index: 64
Published on Mar 1, 2019in Kidney International 8.43
Iryna Schlackow8
Estimated H-index: 8
(University of Oxford),
Seamus Kent7
Estimated H-index: 7
(University of Oxford)
+ 60 AuthorsColin Baigent60
Estimated H-index: 60
(Medical Research Council)
Statin-based treatments reduce cardiovascular disease (CVD) risk in patients with non-dialysis chronic kidney disease (CKD), but it is unclear which regimen is the most cost-effective. We used the Study of Heart and Renal Protection (SHARP) CKD-CVD policy model to evaluate the effect of statins and ezetimibe on quality-adjusted life years (QALYs) and health care costs in the United States (US) and the United Kingdom (UK). Net costs below $100,000/QALY (US) or £20,000/QALY (UK) were considered co...
Source Cite
Published on Mar 1, 2019
Alison Offer9
Estimated H-index: 9
(Clinical Trial Service Unit),
M Arnold1
Estimated H-index: 1
(Clinical Trial Service Unit)
+ 11 AuthorsMartin J. Landray32
Estimated H-index: 32
(Clinical Trial Service Unit)
Importance Acquisition of reliable randomized clinical trial evidence of the effects of cardiovascular interventions on cognitive decline is a priority. Objectives To estimate the association of cognitive aging with the avoidance of vascular events in cardiovascular intervention trials and understand whether reports of nonsignificant results exclude worthwhile benefit. Design, Setting, and Participants This secondary analysis of 3 randomized clinical trials in participants with preexisting occlu...
Source Cite
Published on Feb 1, 2019in The Lancet 53.25
Jane Armitage46
Estimated H-index: 46
,
Colin Baigent60
Estimated H-index: 60
+ 96 AuthorsChristopher P. Cannon131
Estimated H-index: 131
Summary Background Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. Methods In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment dur...
15 Citations Source Cite
Published on Jan 1, 2019in JAMA 47.66
Parish Sarah. , Alison Offer9
Estimated H-index: 9
+ 9 AuthorsMartin J. Landray32
Estimated H-index: 32
12345678910