Rory Collins
Clinical Trial Service Unit
Publications 520
Published on Feb 1, 2019in The Lancet 53.25
Jane Armitage46
Estimated H-index: 46
Colin Baigent56
Estimated H-index: 56
+ 96 AuthorsChristopher P. Cannon130
Estimated H-index: 130
Summary Background Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. Methods In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment dur...
7 Citations Source Cite
Published on Mar 11, 2019in Nature Medicine 32.62
Luanluan Sun (Clinical Trial Service Unit), Robert Clarke84
Estimated H-index: 84
(Clinical Trial Service Unit)
+ 14 AuthorsYiping Chen20
Estimated H-index: 20
(University of Oxford)
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than in Western populations3–5, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of ...
Source Cite
Published on Jan 1, 2019in Journal of the American College of Cardiology 16.83
David Adlam12
Estimated H-index: 12
(National Institute for Health Research),
Timothy Mark Olson28
Estimated H-index: 28
(Mayo Clinic)
+ 234 AuthorsKetan Mishra1
Estimated H-index: 1
(Victor Chang Cardiac Research Institute)
Abstract Background Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, wit...
2 Citations Source Cite
Published on Mar 1, 2019in Kidney International 8.43
Iryna Schlackow8
Estimated H-index: 8
(University of Oxford),
Seamus Kent7
Estimated H-index: 7
(University of Oxford)
+ 60 AuthorsColin Baigent56
Estimated H-index: 56
(Medical Research Council)
Statin-based treatments reduce cardiovascular disease (CVD) risk in patients with non-dialysis chronic kidney disease (CKD), but it is unclear which regimen is the most cost-effective. We used the Study of Heart and Renal Protection (SHARP)CKD-CVD policy model to evaluate the effect of statins and ezetimibe on quality-adjusted life years (QALYs) and healthcare costs in the United States (US) and the United Kingdom (UK). Net costs below $100,000/QALY (US) or £20,000/QALY (UK) were considered cost...
Source Cite
Published on Oct 18, 2018in The New England Journal of Medicine 79.26
Louise Bowman15
Estimated H-index: 15
Marion Mafham8
Estimated H-index: 8
+ 24 AuthorsJane Armitage46
Estimated H-index: 46
© 2018 Massachusetts Medical Society. Background: Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. Methods: We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive aspirin at a dose of 100 mg daily or matching pl...
36 Citations
Published on Aug 1, 2018in European Heart Journal 23.43
Louisa Gnatiuc11
Estimated H-index: 11
(University of Oxford),
J Alegre-Diaz6
Estimated H-index: 6
(National Autonomous University of Mexico)
+ 9 AuthorsRoberto Tapia-Conyer29
Estimated H-index: 29
(National Autonomous University of Mexico)
Source Cite
Published on Aug 1, 2018in European Heart Journal 23.43
David A. Bennett149
Estimated H-index: 149
(University of Oxford),
H. Du (University of Oxford)+ 8 AuthorsZhengming Chen43
Estimated H-index: 43
(University of Oxford)
Source Cite
Published on Mar 19, 2018in The Lancet Diabetes & Endocrinology 19.31
Jonathan Emberson45
Estimated H-index: 45
William G. Herrington12
Estimated H-index: 12
+ 4 AuthorsRichard Peto152
Estimated H-index: 152
Published on Feb 1, 2018in European Heart Journal 23.43
Jemma C. Hopewell37
Estimated H-index: 37
(Clinical Trial Service Unit),
Rainer Malik32
Estimated H-index: 32
(Ludwig Maximilian University of Munich)
+ 2 AuthorsRory Collins128
Estimated H-index: 128
(Clinical Trial Service Unit)
9 Citations Source Cite
Published on Jan 31, 2018in JAMA Cardiology
Theingi Aung6
Estimated H-index: 6
(Medical Research Council),
Jim Halsey8
Estimated H-index: 8
(Medical Research Council)
+ 13 AuthorsPilar Galan78
Estimated H-index: 78
Importance Current guidelines advocate the use of marine-derived omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease, but large trials of omega-3 fatty acids have produced conflicting results. Objective To conduct a meta-analysis of all large trials assessing the associations of omega-3 fatty acid supplements with the risk of fatal and nonfatal coronary heart disease and major vascular events in the fu...
71 Citations Source Cite