Match!

Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

Published on Feb 1, 2018in American Journal of Physiology-gastrointestinal and Liver Physiology3.729
路 DOI :10.1152/ajpgi.00249.2017
John L. Wallace71
Estimated H-index: 71
(U of C: University of Calgary),
Jean-Paul Motta15
Estimated H-index: 15
(U of C: University of Calgary),
Andre G. Buret47
Estimated H-index: 47
(U of C: University of Calgary)
Sources
Abstract
A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions ...
Figures & Tables
  • References (48)
  • Citations (8)
馃摉 Papers frequently viewed together
44 Citations
92 Citations
2 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References48
Newest
#1Walid Mottawea (U of O: University of Ottawa)H-Index: 8
#2Cheng-Kang Chiang (U of O: University of Ottawa)H-Index: 9
Last. Alain Stintzi (U of O: University of Ottawa)H-Index: 32
view all 17 authors...
Intestinal microbial dysbiosis is associated with Crohn鈥檚 disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitocho...
72 CitationsSource
#1Nicolas Cenac (Paul Sabatier University)H-Index: 29
#2M. Castro (Paul Sabatier University)H-Index: 2
Last. Nathalie VergnolleH-Index: 62
view all 7 authors...
Background Trimebutine maleate, a noncompetitive spasmolytic agent with some affinity for peripheral 渭- and 魏-opioid receptors has been evaluated as a treatment in a limited number of patients undergoing sedation-free full colonoscopy. The efficiency of such treatment was comparable to sedation-based colonoscopies to relieve from pain and discomfort. Methods A new and improved trimebutine salt capable of releasing in聽vivo hydrogen sulphide (H2S), a gaseous mediator known to reduce nociception, h...
12 CitationsSource
#1Mark J. Paul-Clark (Imperial College London)H-Index: 26
#2Wagdi Elsheikh (McMaster University)H-Index: 4
Last. John L. Wallace (U of C: University of Calgary)H-Index: 25
view all 12 authors...
Nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence of gastrointestinal cancers, but the propensity of these drugs to cause ulcers and bleeding limits their use. H2S has been shown to be a powerful cytoprotective and anti-inflammatory substance in the digestive system. This study explored the possibility that a H2S-releasing nonsteroidal anti-inflammatory drug (ATB-346) would be effective in a murine model of hereditary intestinal cancer (APCMin+ mouse) and investigated ...
13 CitationsSource
#1Rory W. Blackler (McMaster University)H-Index: 8
#2Giada De Palma (McMaster University)H-Index: 21
Last. John L. Wallace (U of T: University of Toronto)H-Index: 25
view all 9 authors...
The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAID enteropathy, using both a conventional NSAID (naproxen) and a gastrointestinal-safe naproxen derivative (ATB-346), as well as proton pump inhibitors (PPIs). Rats were treated orally with naproxen or equimolar doses of ATB-346 over a 5-day ...
21 CitationsSource
Hydrogen sulfide (H2S) is a ubiquitous gaseous signalling molecule with a plethora of important roles. In this Review, Wallace and Wang describe the pathways for the synthesis and metabolism of H2S and its major mechanisms of action in health and in disease processes, before discussing examples of attempts to exploit the actions of H2S in the design of novel drugs.
263 CitationsSource
#1Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
#2Kyle L. Flannigan (McMaster University)H-Index: 13
Last. John L. Wallace (U of C: University of Calgary)H-Index: 25
view all 10 authors...
61 CitationsSource
#1Rory W. Blackler (McMaster University)H-Index: 8
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last. John L. Wallace (U of C: University of Calgary)H-Index: 25
view all 7 authors...
Background and Purpose Hydrogen sulphide is an important mediator of gastrointestinal mucosal defence. The use of non-steroidal anti-inflammatory drugs (NSAIDs) is significantly limited by their toxicity in the gastrointestinal tract. Particularly concerning is the lack of effective preventative or curative treatments for NSAID-induced intestinal damage and bleeding. We evaluated the ability of a hydrogen sulphide donor to protect against NSAID-induced enteropathy. Experimental Approach Intestin...
28 CitationsSource
Abstract Significance: The current literature regarding the effects of the gaseous signal molecule hydrogen sulfide (H2S) in the gastrointestinal system is reviewed. Bacterial, host and pharmaceutical-derived H2S are all considered and presented according to the physiological or pathophysiological effects of the gaseous signal molecule. These subjects include the toxicology of intestinal H2S with emphasis on bacterial-derived H2S, especially from sulfate-reducing bacteria, the role of endogenous...
71 CitationsSource
#1Malin E. V. Johansson (University of Gothenburg)H-Index: 39
#2Jenny K. Gustafsson (University of Gothenburg)H-Index: 13
Last. Gunnar C. Hansson (University of Gothenburg)H-Index: 62
view all 11 authors...
Objective The inner mucus layer in mouse colon normally separates bacteria from the epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer a common denominator for spontaneous colitis in mice models and ulcerative colitis (UC)? Methods and results The colon mucus layer from mice deficient in Muc2 mucin, Core 1 O -glycans, Tlr5, interleukin 10 (IL-10) and Slc9a3 (Nhe3) together with that from dextran sodium sulfate-treated mice was immunostained for Muc2, and b...
314 CitationsSource
#1Shaolong Feng (Tianjin University of Science and Technology)H-Index: 10
#2Tyson P. Eucker (WSU: Washington State University)H-Index: 7
Last. Shuo Wang (Tianjin University of Science and Technology)H-Index: 39
view all 6 authors...
We present the results of a study using high-throughput whole-transcriptome sequencing (RNA-seq) and vibrational spectroscopy to characterize and fingerprint pathogenic-bacterium injury under conditions of unfavorable stress. Two garlic-derived organosulfur compounds were found to be highly effective antimicrobial compounds against Cronobacter sakazakii, a leading pathogen associated with invasive infection of infants and causing meningitis, necrotizing entercolitis, and bacteremia. RNA-seq show...
15 CitationsSource
Cited By8
Newest
#1Hanshi Wang (PRC: China Medical University (PRC))
#2Xi Li (PRC: China Medical University (PRC))
Last. Xizhuang Bai (PRC: China Medical University (PRC))H-Index: 2
view all 6 authors...
Abstract Apoptosis of osteoblasts plays a crucial role in osteomyelitis. Hydrogen sulfide (H2S) levels are increased in the pathophysiological processes of osteomyelitis. However, the effect of H2S on the apoptosis of osteoblasts remains unclear. To investigate the specific role of H2S in osteoblast apoptosis, MC3T3-E1 and hFOB cells were treated with NaHS or Na2S, a donor of H2S, and lipopolysaccharide (LPS), during osteomyelitis. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ass...
Source
#1Urszula Glowacka (Jagiellonian University Medical College)
#2Tomasz Brzozowski (Jagiellonian University Medical College)H-Index: 28
Last. Marcin Magierowski (Jagiellonian University Medical College)H-Index: 14
view all 3 authors...
Endogenous gas transmitters, hydrogen sulfide (H2S), carbon monoxide (CO) and nitric oxide (NO) are important signaling molecules known to exert multiple biological functions. In recent years, the role of H2S, CO and NO in regulation of cardiovascular, neuronal and digestive systems physiology and pathophysiology has been emphasized. Possible link between these gaseous mediators and multiple diseases as well as potential therapeutic applications has attracted great attention from biomedical scie...
Source
#1Houem RabahH-Index: 8
Last. Gilles GarricH-Index: 2
view all 15 authors...
Backgrounds and Aims. Inflammatory Bowel Diseases (IBD), including Ulcerative Colitis (UC), coincide with alterations in the gut microbiota. Consumption of immunomodulatory strains of probiotic bacteria may induce or prolong remission in UC patients. Fermented foods, including cheeses, constitute major vectors for bacteria consumption. New evidences revealed anti-inflammatory effects in selected strains of Propionibacterium freudenreichii. We thus hypothesized that consumption of a functional ch...
Source
#1Sofia C. Nunes (NSU: Nova Southeastern University)
#2Jacinta Serpa (NSU: Nova Southeastern University)H-Index: 11
Source
#1Carmen Rubio (CSIC: Spanish National Research Council)
#2Marta Puerto (Ciber)H-Index: 2
view all 17 authors...
Abstract Objective Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1B (PTP1B) plays distinct roles in non-immune and immune cells, in the latter inhibiting pro-inflammatory signaling cascades. In this study we have explored the role of PTP1B in the composition of gut microbiota and gut barrier dynamics in methionine and choline-d...
Source
#1Hai-Jian SunH-Index: 1
#2Zhiyuan WuH-Index: 7
Last. Jin-Song BianH-Index: 39
view all 4 authors...
Endothelial cells are important constituents of blood vessels that play critical roles in cardiovascular homeostasis by regulating blood fluidity and fibrinolysis, vascular tone, angiogenesis, monocyte/leukocyte adhesion and platelet aggregation. The normal vascular endothelium is taken as a gatekeeper of cardiovascular health, whereas abnormality of vascular endothelium is a major contributor to a plethora of cardiovascular ailments, such as atherosclerosis, aging, hypertension, obesity and dia...
Source
#1Yingnan Han (SDU: Shandong University)H-Index: 2
#2Ya Li (SDU: Shandong University)
Last. Yundong Sun (SDU: Shandong University)H-Index: 6
view all 10 authors...
Chronic persistent stress is an important cause of gastritis, but the underlying mechanism remains to be further researched, especially the role of the gastric microbiota in this process. Here, we used the water avoidance stress (WAS) test in mouse models for chronic stress鈥恑nduced gastritis to investigate the underlying mechanisms of this disease. The effect of stress on the gastric microbiota was analyzed based on 16S rRNA sequencing; the changes in hydrogen sulfide (H2S) and inflammatory cyto...
Source
#1Jean-Paul Motta (University of Toulouse)H-Index: 15
#2Alexandre Denadai-Souza (University of Toulouse)H-Index: 7
Last. Nathalie Vergnolle (University of Toulouse)H-Index: 62
view all 23 authors...
Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence of commensal microbiota. Specific inhibition of luminal thrombin activity causes macroscopic and microscopic damage as well as transcriptomic alterations of genes involved in host-microbiota interacti...
Source
#1Almut Heinken (NUI: National University of Ireland)
#2Ines Thiele (NUI: National University of Ireland)H-Index: 42
Abstract The human gut microbiome plays an important role in human health. In order to investigate changes in metabolic activity associated with dysbiotic microbiomes, we retrieved strain-level relative abundances from metagenomics data from a cohort of pediatric Crohn鈥檚 Disease patients with and without dysbiosis, and healthy control children to construct a personalized microbiome model for each sample using the AGORA resource of genome-scale gut microbial reconstructions. Subsequently, we syst...
Source
#1Spencer C. Peck (Harvard University)H-Index: 1
#2Karin Denger (University of Konstanz)H-Index: 25
Last. David Schleheck (University of Konstanz)H-Index: 19
view all 6 authors...
Hydrogen sulfide (H 2 S) production in the intestinal microbiota has many contributions to human health and disease. An important source of H 2 S in the human gut is anaerobic respiration of sulfite released from the abundant dietary and host-derived organic sulfonate substrate in the gut, taurine (2-aminoethanesulfonate). However, the enzymes that allow intestinal bacteria to access sulfite from taurine have not yet been identified. Here we decipher the complete taurine desulfonation pathway in...
9 CitationsSource