Hydrogen sulfide: an agent of stability at the microbiome-mucosa interface

Published on Feb 1, 2018in American Journal of Physiology-gastrointestinal and Liver Physiology3.729
路 DOI :10.1152/ajpgi.00249.2017
John L. Wallace71
Estimated H-index: 71
(U of C: University of Calgary),
Jean-Paul Motta15
Estimated H-index: 15
(U of C: University of Calgary),
Andre G. Buret47
Estimated H-index: 47
(U of C: University of Calgary)
A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide. H2S donors can modify the gut microbiota, and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H2S. When administered together with nonsteroidal anti-inflammatory drugs, H2S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. Exogenous H2S can also markedly reduce the severity of experimental colitis and plays important roles in modulating epithelial cell-mucus-bacterial interactions ...
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