Match!
John L. Wallace
University of Calgary
EndocrinologyInflammationStomachMedicinePharmacology
344Publications
71H-index
14.1kCitations
What is this?
Publications 394
Newest
#1Anna Manko-Prykhoda (U of C: University of Calgary)
#2Thibault Allain (U of C: University of Calgary)H-Index: 5
Last. Paul L. Beck (U of C: University of Calgary)H-Index: 51
view all 11 authors...
Abstract Polymicrobial infections of the gastro-intestinal tract are common in areas with poor sanitation. Disease outcome is the result of complex interactions between the host and pathogens. Such interactions lie at the core of future management strategies of enteric diseases. In developed countries of the world, Giardia duodenalis is a common cause of diarrheal disease. In contrast, giardiasis appears to protect children against diarrhea in countries with poor sanitation, via obscure mechanis...
Source
#1Soraia K.P. Costa (USP: University of São Paulo)H-Index: 16
#2Marcelo N. Muscará (USP: University of São Paulo)H-Index: 33
Last. John L. Wallace (U of C: University of Calgary)H-Index: 71
view all 10 authors...
AIMS The covalent linking of non-steroidal anti-inflammatory drugs (NSAIDs) to a hydrogen sulfide (H2S)-releasing moiety has been shown to dramatically reduce gastrointestinal (GI) damage and bleed...
Source
#1John L. WallaceH-Index: 71
#2Nancy I.A. BylesH-Index: 2
view all 3 authors...
Source
#1John L. Wallace (U of C: University of Calgary)H-Index: 71
#2Péter Nagy (University of Debrecen)H-Index: 28
Last. Andre G. Buret (University of Debrecen)H-Index: 47
view all 9 authors...
1 CitationsSource
#1Andreas Papapetropoulos (UoA: National and Kapodistrian University of Athens)H-Index: 50
#2John L. Wallace (U of C: University of Calgary)H-Index: 71
Last. Rui Wang (York University)
view all 3 authors...
Source
#1Mark G. Swain (U of C: University of Calgary)H-Index: 40
#2John L. Wallace (U of C: University of Calgary)H-Index: 71
Last. Francis H. Y. Green (U of C: University of Calgary)H-Index: 39
view all 10 authors...
The purpose of this study was to determine the efficacy of a Peruvian botanical formulation for treating disorders of hepatic function and gastric mucosal integrity. The formulation A4+ (Sabell Corporation) contains extracts of Curcuma longa rhizome, Cordia lutea flower, and Annona muricata leaf. Individually these plants have been used as traditional remedies for liver disease. We report the efficacy of A4+ and its components using a variety of in vitro and in vivo disease models. The methods u...
Source
#1Jean-Paul Motta (University of Toulouse)H-Index: 15
#2Alexandre Denadai-Souza (University of Toulouse)H-Index: 7
Last. Nathalie Vergnolle (University of Toulouse)H-Index: 62
view all 23 authors...
Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence of commensal microbiota. Specific inhibition of luminal thrombin activity causes macroscopic and microscopic damage as well as transcriptomic alterations of genes involved in host-microbiota interacti...
Source
#1John L. WallaceH-Index: 71
#2Andre G. BuretH-Index: 47
Last. Gilberto De NucciH-Index: 36
view all 5 authors...
Background: Hydrogen sulfide (H2S) is a naturally occurring gaseous mediator produced by intestinal bacteria and various eukaryotic cells. H2S exerts anti-inflammatory, pro-resolution and cytoprotective effects in vivo. ATB-346 is an H2S-releasing derivative of naproxen, which in animals was shown to produce negligible gastrointestinal (GI) damage and bleeding. In human studies, ATB-346 was found to be much more potent and long-lasting than naproxen. A phase 2 open-label efficacy study demonstra...
Source
Source
#1John L. Wallace (U of C: University of Calgary)H-Index: 71
5 CitationsSource
12345678910