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Jean-Paul Motta
University of Toulouse
42Publications
15H-index
712Citations
Publications 42
Newest
#1Andre G. Buret (U of C: University of Calgary)H-Index: 47
#2Jean-Paul Motta (University of Toulouse)H-Index: 15
Last.John L. Wallace (U of C: University of Calgary)H-Index: 71
view all 5 authors...
Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these microbiota communities, and how in turn their disruptions may cause disease. Beyond alterations of relative microbial abundance and diversity, the aim of the review is to focus on the disruptions of the microbiota biofilm structure and function, the dispersion of commensal bacteria, and the mech...
7 CitationsSource
#1Jean-Paul Motta (University of Toulouse)H-Index: 15
#2Alexandre Denadai-Souza (University of Toulouse)H-Index: 7
Last.Nathalie Vergnolle (University of Toulouse)H-Index: 62
view all 23 authors...
Proteolytic homeostasis is important at mucosal surfaces, but its actors and their precise role in physiology are poorly understood. Here we report that healthy human and mouse colon epithelia are a major source of active thrombin. We show that mucosal thrombin is directly regulated by the presence of commensal microbiota. Specific inhibition of luminal thrombin activity causes macroscopic and microscopic damage as well as transcriptomic alterations of genes involved in host-microbiota interacti...
Source
#1Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
#2Thibault Allain (U of C: University of Calgary)H-Index: 5
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 10 authors...
5 CitationsSource
#1Christina B. Amat (U of C: University of Calgary)H-Index: 5
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 4 authors...
Source
#1Anna Manko (U of C: University of Calgary)H-Index: 3
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 7 authors...
Source
#1John L. Wallace (U of C: University of Calgary)H-Index: 71
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 3 authors...
A diverse range of effects of the intestinal microbiota on mucosal defense and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defense and repair. Hydrogen sulfide is produced by gastrointestinal tract tissues and by bacteria residing within the gut and can influence the function of a wide range of cells. The microbiota also appears to be an important target ...
8 CitationsSource
#1Christina B. Amat (U of C: University of Calgary)H-Index: 5
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 5 authors...
The intestinal mucous layer provides a critical host defense against pathogen exposure and epithelial injury, yet little is known about how enteropathogens may circumvent this physiologic barrier. Giardia duodenalis is a small intestinal parasite responsible for diarrheal disease and chronic postinfectious illness. This study reveals a complex interaction at the surface of epithelial cells, between G. duodenalis and the intestinal mucous layer. Here, we reveal mechanisms whereby G. duodenalis ev...
9 CitationsSource
#1Claire Rolland-Fourcade (University of Toulouse)H-Index: 1
#2Alexandre Denadai-Souza (University of Toulouse)H-Index: 7
Last.Nathalie Vergnolle (University of Toulouse)H-Index: 62
view all 20 authors...
Objectives Proteases are key mediators of pain and altered enteric neuronal signalling, although the types and sources of these important intestinal mediators are unknown. We hypothesised that intestinal epithelium is a major source of trypsin-like activity in patients with IBS and this activity signals to primary afferent and enteric nerves and induces visceral hypersensitivity. Design Trypsin-like activity was determined in tissues from patients with IBS and in supernatants of Caco-2 cells sti...
26 CitationsSource
#1Rebeca Martín (Université Paris-Saclay)H-Index: 22
#2Florian Chain (Université Paris-Saclay)H-Index: 17
Last.Philippe Langella (Université Paris-Saclay)H-Index: 57
view all 7 authors...
8 CitationsSource
#1Anna Manko (U of C: University of Calgary)H-Index: 3
#2Jean-Paul Motta (U of C: University of Calgary)H-Index: 15
Last.Andre G. Buret (U of C: University of Calgary)H-Index: 47
view all 8 authors...
Our understanding of polymicrobial gastrointestinal infections and their effects on host biology remains incompletely understood. Giardia duodenalis is an ubiquitous intestinal protozoan parasite infecting animals and humans. Concomitant infections with Giardia and other gastrointestinal pathogens commonly occur. In countries with poor sanitation, Giardia infection has been associated with decreased incidence of diarrheal disease and fever, and reduced serum inflammatory markers release, via mec...
15 CitationsSource
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