Hematopoietic stem cells are active contributors to hematopoiesis in steady state

Hematopoietic Stem Cells Are Active Contributors to Hematopoiesis in Steady State Definitive hematopoietic stem cell (HSC) function has historically been evaluated using transplantation. In this setting, self-renewal and potent long-term multilineage contribution can be observed from even single HSCs. However, recent reports regarding HSC contribution to native hematopoiesis have suggested fundamental differences between post-transplantation and...