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Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans

Published on Aug 1, 2017in Cell Metabolism22.41
· DOI :10.1016/j.cmet.2017.07.008
Norbert Stefan59
Estimated H-index: 59
(University of Tübingen),
Fritz Schick61
Estimated H-index: 61
(University of Tübingen),
Hu Häring85
Estimated H-index: 85
(University of Tübingen)
Abstract
A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (∼20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.
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References83
Newest
#1Unjali P. Gujral (Emory University)H-Index: 6
#2Eric Vittinghoff (UCSF: University of California, San Francisco)H-Index: 101
Last.Alka M. Kanaya (UCSF: University of California, San Francisco)H-Index: 50
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#1Norbert Stefan (University of Tübingen)H-Index: 59
#2Andreas Fritsche (University of Tübingen)H-Index: 71
Last.Hu Häring (University of Tübingen)H-Index: 85
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#1Hanieh Yaghootkar (University of Exeter)H-Index: 28
#2Luca A. Lotta (University of Cambridge)H-Index: 12
Last.Caroline Hayward (Edin.: University of Edinburgh)H-Index: 86
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#1Steven P. Marso (UTSW: University of Texas Southwestern Medical Center)H-Index: 20
#2Gilbert H. Daniels (Harvard University)H-Index: 44
Last.Lasse Steen Ravn (Novo Nordisk)H-Index: 4
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#2Paula M Miotto (University of Melbourne)
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#2Theresia M. Schnurr (UCPH: University of Copenhagen)H-Index: 3
Last.Christine Frithioff-Bøjsøe (UCPH: University of Copenhagen)H-Index: 1
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#1Dong Hee Kim (Stanford University)H-Index: 38
#2Donghee Kim (Stanford University)H-Index: 29
Last.Aijaz Ahmed (Stanford University)H-Index: 28
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#1Guo-Chong Chen (Albert Einstein College of Medicine)
#2Rhonda Arthur (Albert Einstein College of Medicine)H-Index: 3
Last.Yangbo Sun (UI: University of Iowa)
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#1Giulia Ratrelli (UniFI: University of Florence)H-Index: 37
#2Francesco Lotti (UniFI: University of Florence)H-Index: 32
Last.Giovanni CoronaH-Index: 60
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