Norbert Stefan
University of Tübingen
Publications 379
#1Anja Schork (University of Tübingen)H-Index: 3
Last.Ferruh Artunc (University of Tübingen)H-Index: 22
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Background SGLT2-inhibitors are potent antihyperglycemic drugs for patients with type 2 diabetes and have been shown to reduce body weight. However, it is unclear which body compartments are reduced and to what extent.
#1Katarzyna Linder (University of Tübingen)H-Index: 12
#2Caroline Willmann (University of Tübingen)
Last.Norbert Stefan (University of Tübingen)H-Index: 59
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Niacin inhibits fatty acid flux from adipose tissue to liver, reduces hepatic triglyceride synthesis and increases hepatic lipid oxidation. Thus, niacin may have a role in the regulation of liver fat content in humans. We tested if dietary intake of niacin predicts change of liver fat content during a lifestyle intervention. To this end, we estimated the composition of diet from diaries of 202 healthy subjects at risk of type 2 diabetes undergoing lifestyle intervention comprising physical activ...
#1Cornelia BrendleH-Index: 11
#2Norbert StefanH-Index: 59
Last.Christina PfannenbergH-Index: 34
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Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several external factors and diverse chemotherapeutic and immunosuppressive agents in a collective of 702 patients. The patients underwent at least two clinically indicated PET/CT examinatio...
#1S. Kahl (HHU: University of Düsseldorf)H-Index: 7
#2Sofiya Gancheva (HHU: University of Düsseldorf)H-Index: 3
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OBJECTIVE To evaluate whether the sodium–glucose cotransporter 2 inhibitor empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically well-controlled type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS Patients with T2D (n = 84) (HbA1c 6.6 ± 0.5% [49 ± 10 mmol/mol], known disease duration 39 ± 27 months) were randomly assigned to 24 weeks of treatment with 25 mg daily EMPA or placebo. The primary end point was the difference of the change in LFC as measured with magnet...
#2Olga KuxhausH-Index: 4
Last.Matthias B. Schulze (University of Potsdam)H-Index: 67
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Aims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers.
#1Ba Jaghutriz (University of Tübingen)H-Index: 1
#2Robert Wagner (University of Tübingen)H-Index: 15
Last.Andreas Fritsche (University of Tübingen)H-Index: 71
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Objective Pancreatic steatosis is associated with impaired beta cell function in patients with prediabetes. The pathomechanisms underlying this association still remain to be elucidated. Recent data show that adipocytes are situated within the pancreatic parenchyma and therefore give raise to hypothesize that pancreatic fat together with known and unknown metabolites such as hepatokines affect insulin secretion. Applying a targeted metabolomic approach we investigated possible circulating marker...