Development of membrane ion channels during neural differentiation from human embryonic stem cells

For human embryonic stem cells (hESCs) to differentiate into neurons, enormous changes has to occur leading to trigger action potential and neurotransmitter release. We attempt to determine the changes in expression of voltage gated channels (VGCs) and their electrophysiological properties during neural differentiation.The relative expressions of α-subunit of voltage gated potassium, sodium and calcium channels were characterized by qRT-PCR...