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Biochemical and Biophysical Research Communications
IF
2.71
Papers
90833
Papers 91536
1 page of 9,154 pages (91.5k results)
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Debika Ojha (CSIR: Council of Scientific and Industrial Research), K. Neelakanteshwar Patil (CSIR: Council of Scientific and Industrial Research)
Abstract Bacterial RecA plays an important role in the evaluation of antibiotic resistance via stress-induced DNA repair mechanism; SOS response. Accordingly, RecA became an important therapeutic target against antimicrobial resistance. Small molecule inhibitors of RecA may prevent adaptation of antibiotic resistance mutations and the emergence of antimicrobial resistance. In our study, we observed that phenolic compound p-Coumaric acid as potent RecA inhibitor. It inhibited RecA driven biochemi...
Seisuke Mimori4
Estimated H-index: 4
(Chiba Institute of Science),
Koichi Kawada12
Estimated H-index: 12
(Chiba Institute of Science)
+ -3 AuthorsTetsuto Kanzaki20
Estimated H-index: 20
(Chiba University)
Abstract Insoluble aggregated proteins are often associated with neurodegenerative diseases. Previously, we investigated chemical chaperones that prevent the aggregation of denatured proteins. Among these, 4-phenyl butyric acid (4-PBA) has well-documented chemical chaperone activity, but is required at doses that have multiple effects on cells, warranting further optimization of treatment regimens. In this study, we demonstrate chemical chaperone activities of the novel compound indole-3-propion...
Ryotaro Kojima (Meiji University), Kotaro Horiguchi10
Estimated H-index: 10
(Kyorin University)
+ -3 AuthorsHideaki Tomura24
Estimated H-index: 24
(Meiji University)
Abstract Extracellular acidification regulates endocrine cell functions. Ovarian cancer G protein-coupled receptor 1 (OGR1), also known as GPR68, is a proton-sensing G protein-coupled receptor and is activated by extracellular acidification, resulting in the activation of multiple intracellular signaling pathways. In the present study, we found that OGR1 was expressed in some gonadotropic cells in rat anterior pituitary and in LβΤ2 cells, which are used as a model of gonadotropic cells. When we ...
Fang-Feng Chiu (NIH: National Institutes of Health), Chih-Hsiang Leng16
Estimated H-index: 16
(PRC: China Medical University (PRC))
+ -3 AuthorsShih-Jen Liu17
Estimated H-index: 17
(PRC: China Medical University (PRC))
Abstract The pneumolysin (Ply) protein of Streptococcus pneumoniae is composed of four domains and possesses several different but related activities. In this study, recombinant Ply and two truncated forms, Ply domain 1-3 and Ply domain 4 (rPly4), were expressed and characterized regarding their participation in apoptosis, the stimulation of cytokine production, hemolytic activity and virulence. rPly4 activated murine bone marrow-derived dendritic cells in a Toll-like receptor (TLR) 4-dependent ...
Priscila Calle1
Estimated H-index: 1
(CSIC: Spanish National Research Council),
Selene Torrico (CSIC: Spanish National Research Council)+ -3 AuthorsGeorgina Hotter28
Estimated H-index: 28
(CSIC: Spanish National Research Council)
Abstract Background Dyslipidemia causes renal damage; however, the detailed molecular mechanism has not been clarified. It is known that carnitine palmitoyl transferase 1-a (CPT1a) gene encodes an enzyme involved in fatty acid oxidation and, therefore, lipid content. In the present study, we investigated whether the accumulation of lipids induced by 7-ketocholesterol (7-KC) in tubular epithelial cells produce a fibrotic and inflammatory response through CPT1a. Methods Using an epithelial cell li...
Kiyohiro Takahasi (Gakushuin University), Koji Onomoto11
Estimated H-index: 11
(Chiba University)
+ -3 AuthorsMitsutoshi Yoneyama41
Estimated H-index: 41
(Chiba University)
Abstract Upon viral infection, retinoic acid-inducible gene-I (RIG-I)-like receptors detect viral foreign RNAs and transmit anti-viral signals via direct interaction with the downstream mitochondrial adaptor molecule, interferon (IFN)-β promoter stimulator-1 (IPS-1), to inhibit viral replication. Although IPS-1 is known to form prion-like oligomers on mitochondria to activate signaling, the mechanisms that regulate oligomer formation remain unclear. Here, we identified an autoinhibitory domain (...
Jun Wang (Nantong University), Chang Cai + -3 AuthorsHonglin Chen
Abstract Fyn-related kinase (FRK), a member of the Src-related tyrosine kinase family, functions as a tumor suppressor in several malignancies. We previously showed that FRK overexpression inhibited the growth of glioma cells. However, it is unknown whether FRK is equally effective against intracranial glioma in vivo, and the mechanism by which FRK influences glioma cell growth remains unclear. In this study, we found that tumor volume was reduced by about one-third in mice with FRK overexpressi...
Huabo He (Hangzhou Normal University), Wei Wu (Hangzhou Normal University)+ -3 AuthorsLixin Chai (Hangzhou Normal University)
Abstract Gastric cancer (GC) has been recognized as the major reason for global cancer-associated mortality. SEC62 homolog, preprotein translocation factor (SEC62) has been documented to possess carcinogenic functions in cancers, but its influence on GC remains elusive. Present study aimed to uncover the impact and mechanism of SEC62 in GC. We validated the upregulation of SEC62 in GC samples by GEPIA, and revealed its high level in GC cell lines. Functionally, depletion of SEC62 hindered prolif...
Abstract Spinal cord injury (SCI) is a devastating neurological condition that results in progressive tissue loss, secondary to vascular dysfunction and inflammation. Lack of effective pharmacotherapies for SCI is mainly attributable to an incomplete understanding of its pathogenesis. Stimulator of interferon gene (Sting), also known as Transmembrane protein 173 (TMEM173), activates the type I interferon-regulated innate immune response, playing crucial role in modulating inflammation. However, ...
Minting Liang (CAS: Chinese Academy of Sciences), David W. Ow39
Estimated H-index: 39
(CAS: Chinese Academy of Sciences)
Abstract Survival of a species depends on reproductive fitness and a plant's floral transition is controlled by developmental and environmental signals. In Arabidopsis, the floral integrators SOC1 (SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1) and FT (FLOWERING LOCUS T) sense various pathway signals to activate floral meristem identity genes. At high stress intensity, greater nuclear accumulation of the zinc-finger transcription factor OXS2 (OXIDATIVE STRESS 2) activates an early-flowering stress-...
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