Sara Mirsadeghi
Royan Institute
Publications 4
Zeinab Golgooni (Sharif University of Technology), Sara Mirsadeghi1
Estimated H-index: 1
(Royan Institute)
+ 4 AuthorsHamid R. Rabiee17
Estimated H-index: 17
(Sharif University of Technology)
An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem cells (hPSC) derived cardiomyocytes (hPSC-CM) by multi-electrode array (MEA) system. We included field potentials from 380 experiments, which were labeled as normal or arrhythmic by electrophysiology expert...
Published on Sep 1, 2017in Biochemical and Biophysical Research Communications2.71
Sara Mirsadeghi1
Estimated H-index: 1
(Royan Institute),
Ebrahim Shahbazi7
Estimated H-index: 7
(Royan Institute)
+ 4 AuthorsSahar Kiani14
Estimated H-index: 14
(Royan Institute)
Abstract Objective For human embryonic stem cells (hESCs) to differentiate into neurons, enormous changes has to occur leading to trigger action potential and neurotransmitter release. We attempt to determine the changes in expression of voltage gated channels (VGCs) and their electrophysiological properties during neural differentiation. Materials and methods The relative expressions of α-subunit of voltage gated potassium, sodium and calcium channels were characterized by qRT-PCR technique. Pa...