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Sara Mirsadeghi
Royan Institute
4Publications
1H-index
3Citations
Publications 5
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#1Masoumeh Zarei‐Kheirabadi (Royan Institute)
#2Sara Mirsadeghi (Royan Institute)H-Index: 1
Last.Sahar Kiani (Royan Institute)H-Index: 14
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#1Atiyeh Mohammadshirazi (University of Science and Culture)
Last.Sahar Kiani (Royan Institute)H-Index: 14
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#1Zeinab Golgooni (Sharif University of Technology)
#2Sara Mirsadeghi (Royan Institute)H-Index: 1
Last.Hamid R. Rabiee (Sharif University of Technology)H-Index: 20
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An early characterization of drug-induced cardiotoxicity may be possible by combining comprehensive in vitro proarrhythmia assay and deep learning techniques. We aimed to develop a method to automatically detect irregular beating rhythm of field potentials recorded from human pluripotent stem cells (hPSC) derived cardiomyocytes (hPSC-CM) by multi-electrode array (MEA) system. We included field potentials from 380 experiments, which were labeled as normal or arrhythmic by electrophysiology expert...
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#1Sara Mirsadeghi (Royan Institute)H-Index: 1
#2Ebrahim Shahbazi (Royan Institute)H-Index: 8
Last.Sahar Kiani (Royan Institute)H-Index: 14
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Abstract Objective For human embryonic stem cells (hESCs) to differentiate into neurons, enormous changes has to occur leading to trigger action potential and neurotransmitter release. We attempt to determine the changes in expression of voltage gated channels (VGCs) and their electrophysiological properties during neural differentiation. Materials and methods The relative expressions of α-subunit of voltage gated potassium, sodium and calcium channels were characterized by qRT-PCR technique. Pa...
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