Original paper
Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
Abstract
Off-target or random integration of exogenous DNA hampers precise genomic engineering and presents a safety risk in clinical gene therapy strategies. Genetic definition of random integration has been lacking for decades. Here, we show that the A-family DNA polymerase θ (Pol θ) promotes random integration, while canonical non-homologous DNA end joining plays a secondary role; cells double deficient for polymerase θ and canonical non-homologous...
Paper Details
Title
Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA
Published Date
Jul 7, 2017
Journal
Volume
8
Issue
1
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Notes
History