Physical activity modifies the influence of apolipoprotein E ε4 allele and type 2 diabetes on dementia and cognitive impairment among older Mexican Americans

Introduction The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions. Methods We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E ( APOE ) ε4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10...