cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial–mesenchymal transition of hepatocellular carcinoma cells
Abstract
Cytosolic phospholipase A2α (cPLA2α), a key phospholipase that regulates lipid metabolism, plays an important role in tumor progression. In the present study of hepatocellular carcinoma (HCC), cPLA2α was overexpressed in highly metastatic HCC cell lines. Immunohistochemical staining showed increased levels of cPLA2α at the invasive edges of HCC, and a clinicopathological analysis of samples from 111 patients revealed that its expression level...
Paper Details
Title
cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial–mesenchymal transition of hepatocellular carcinoma cells
Published Date
Sep 1, 2017
Journal
Volume
403
Pages
260 - 270
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Notes
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