Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice
Abstract
Sexual dimorphisms are prevalent in development, physiology and diseases in humans. Currently, the contributions of the genes on the male-specific region of the Y chromosome (MSY) in these processes are uncertain. Using a transgene activation system, the human sex-determining gene hSRY is activated in the single-cell embryos of the mouse. Pups with hSRY activated (hSRY ON ) are born of similar sizes as those of non-activated controls. However,...
Paper Details
Title
Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice
Published Date
Jun 23, 2017
Journal
Volume
7
Issue
1
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