Original paper
Independent and Stochastic Action of DNA Polymerases in the Replisome
Abstract
It has been assumed that DNA synthesis by the leading- and lagging-strand polymerases in the replisome must be coordinated to avoid the formation of significant gaps in the nascent strands. Using real-time single-molecule analysis, we establish that leading- and lagging-strand DNA polymerases function independently within a single replisome. Although average rates of DNA synthesis on leading and lagging strands are similar, individual...
Paper Details
Title
Independent and Stochastic Action of DNA Polymerases in the Replisome
Published Date
Jun 1, 2017
Journal
Volume
169
Issue
7
Pages
1201 - 1213.e17
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Notes
History