An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances

Published on Aug 1, 2017in Biomedicine & Pharmacotherapy3.743
· DOI :10.1016/j.biopha.2017.06.003
Majid Zeinali3
Estimated H-index: 3
(MUMS: Mashhad University of Medical Sciences),
Seyed Abdolrahim Rezaee9
Estimated H-index: 9
Hossein Hosseinzadeh49
Estimated H-index: 49
(MUMS: Mashhad University of Medical Sciences)
Abstract Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system. CH possesses potent immune-protective effects and suppresses inflammation in innate immune system which results to avoid damages induced by neutrophils and macrophages and suppresses immuno-inflammatory responses. Furthermore, beneficial effects of chrysin on inhibition of serum levels nuclear transcription factor κB (NF-κB) p65 unit, tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-12, IL-17A, interferon gamma (IFN-γ) was reported. Moreover, CH has been known as the antagonist of NF-kB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ) which in down regulation of the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids. Therefore, CH can improve immune system and neurodegenerative diseases. In recent years, there has been an increasing interest in compound derivatives from natural origin. Taken together, evidences show that flavonoids may have health-promoting and disease-preventing dietary compounds with important benefits in modern life styles.
  • References (96)
  • Citations (32)
📖 Papers frequently viewed together
79 Citations
48 Citations
148 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Xiangda Meng (Tianjin Medical University General Hospital)H-Index: 5
#2Sijie Fang (Tianjin Medical University General Hospital)H-Index: 2
Last. Hua Yan (Tianjin Medical University General Hospital)H-Index: 9
view all 7 authors...
Uveitis is a common cause of blindness worldwide. Experimental autoimmune uveitis (EAU) is an animal model of noninfectious uveitis. Chrysin (5,7-dihydroxyflavone) is a member of the flavonoid family and has anti-inflammatory effects. We immunized C57BL/6J mice with human interphotoreceptor retinoid-binding protein peptide 1–20 to induce EAU. Chrysin was administered intragastrically at 25 mg/kg daily to the chrysin-treated mice from 3 days before immunization to 21 days after immunization. Vehi...
5 CitationsSource
#1Kamal Razavi-Azarkhiavi (MUMS: Mashhad University of Medical Sciences)H-Index: 6
#2Milad Iranshahy (MUMS: Mashhad University of Medical Sciences)H-Index: 12
Last. Gholamreza Karimi (MUMS: Mashhad University of Medical Sciences)H-Index: 23
view all 5 authors...
ABSTRACTAlthough doxorubicin (DOX) is among the most widely used anticancer agents, its clinical application is hampered owing to its cardiotoxicity. Adjuvant therapy with an antioxidant has been suggested as a promising strategy to reduce DOX-induced adverse effects. In this context, many phenolic compounds have been reported to protect against DOX-induced cardiotoxicity. The cardioprotective effects of phenolic compounds are exerted via multiple mechanisms including inhibition of reactive oxyg...
16 CitationsSource
#1Jiri Mlcek (Tomas Bata University in Zlín)H-Index: 21
#2Tunde JurikovaH-Index: 21
Last. Jiri Sochor (Tomas Bata University in Zlín)H-Index: 2
view all 4 authors...
Quercetin is the great representative of polyphenols, flavonoids subgroup, flavonols. Its main natural sources in foods are vegetables such as onions, the most studied quercetin containing foods, and broccoli; fruits (apples, berry crops, and grapes); some herbs; tea; and wine. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflam...
42 CitationsSource
#1Teresa VezzaH-Index: 8
Last. Julio GálvezH-Index: 46
view all 6 authors...
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients’ life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavon...
61 CitationsSource
#1Jing Yao (Nanjing Medical University)H-Index: 2
#2Mingzi JiangH-Index: 1
Last. Ganzhu Feng (Nanjing Medical University)H-Index: 3
view all 6 authors...
Asthma is a chronic airway inflammatory disorder and progresses mainly due to airway remodeling. Chrysin, a natural flavonoid, has been reported to possess multiple biologic activities, including anti-inflammation, anti-oxidation and anti-proliferation. The present study aimed to investigate whether chrysin could relieve allergic airway inflammation and remodeling in a murine model of chronic asthma and the mechanism involved. The female BALB/c mice sensitized and challenged with ovalbumin (OVA)...
8 CitationsSource
#1Yu Ming Hsu (KMU: Kaohsiung Medical University)H-Index: 7
#2Tung Ying Wu (PRC: China Medical University (PRC))H-Index: 12
Last. WuYang-ChangH-Index: 47
view all 10 authors...
Abstract The phytochemical investigation of the methanolic extract of Uvaria flexuosa (Annonaceae) leaves led to the isolation of seven compounds including, 3-methyl-4,5-dihydro-oxepine (flexuvaroxepine A), four polyoxygenated seco-cyclohexene (flexuvarin A–D) and two polyoxygenated cyclohexene (flexuvarol A–B) derivatives, together with four known flavones. The structures of the isolated compounds were elucidated using different spectroscopic techniques. A plausible biogenetic route of the new ...
12 CitationsSource
#1Leandro Cattelan Souza (Universidade Federal do Pampa)H-Index: 11
#2Michelle S. Antunes (Universidade Federal do Pampa)H-Index: 8
Last. Cristiano Ricardo Jesse (Universidade Federal do Pampa)H-Index: 26
view all 10 authors...
Abstract In this study, the effect of Chrysin (5,7-dihydroxyflavone), an important member of the flavonoid family, on memory impairment, oxidative stress and BDNF reduction generated by aging in mice were investigated. Young and aged mice were treated daily per 60 days with Chrysin (1 and 10 mg/kg; per oral, p.o.) or veichle (10 ml/kg; p.o.). Mice were trained and tested in Morris Water Maze task. After the behavioural test, the levels of reactive species (RS), the activity of superoxide dismuta...
31 CitationsSource
In the recently published paper by Xie et al1 in the journal of Drug Design, Development and Therapy, the authors have evaluated interleukin (IL)-17–driven inflammatory responses in 17 cases of human colon adenocarcinomas, 16 cases of human normal colon tissues adjacent to the resected colon adenocarcinomas, ten cases of human ulcerative colitis tissues from biopsies, and eight cases of human benign colon polyps. The authors have observed that human colon adenocarcinomas contained the highest le...
12 CitationsSource
#1Natasa IsailovicH-Index: 6
#2Kenji DaigoH-Index: 13
Last. Carlo Selmi (University of Milan)H-Index: 56
view all 4 authors...
Abstract Interleukin 17 (IL-17) includes several cytokines among which IL-17A is considered as one of the major pro-inflammatory cytokine being central to the innate and adaptive immune responses. IL-17 is produced by unconventional T cells, members of innate lymphoid cells (ILCs), mast cells, as well as typical innate immune cells, such as neutrophils and macrophages located in the epithelial barriers and characterised by a rapid response to infectious agents by recruiting neutrophils as first ...
153 CitationsSource
#1Haruko Watanabe-Takano (Chiba University)H-Index: 11
#2Kazunori Takano (Chiba University)H-Index: 12
Last. Takeshi Endo (Chiba University)H-Index: 33
view all 5 authors...
Myofibroblasts play critical roles in the development of idiopathic pulmonary fibrosis by depositing components of extracellular matrix. One source of lung myofibroblasts is thought to be alveolar epithelial type 2 cells that undergo epithelial–mesenchymal transition (EMT). Rat RLE-6TN alveolar epithelial type 2 cells treated with transforming growth factor-β1 (TGF-β1) are converted into myofibroblasts through EMT. TGF-β induces both canonical Smad signaling and non-canonical signaling, includin...
13 CitationsSource
Cited By32
#1Sun Jun (Jiangsu University)H-Index: 8
#2Yaoyao Mu (Jiangsu University)H-Index: 2
Last. Bin Xu (Jiangsu University)H-Index: 4
view all 5 authors...
Propolis has attracted commercial interest as a good source of flavonoids and terpenes. This study applied a two-step sequential extraction process, consisting of a super/subcritical extraction ste...
#1Quan Wen (Guangzhou University of Chinese Medicine)H-Index: 3
#1Quan Wen (Guangzhou University of Chinese Medicine)
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 6
view all 14 authors...
Inflammation is a common inducer of numerous severe diseases such as sepsis. The NF-κB signaling pathway plays a key role in the inflammatory process. Its activation promotes the release of pro-inf...
#1Jae-Seung Hong (Hallym University)H-Index: 3
#2Jing-Hui Feng (Hallym University)
Last. Hong-Won Suh (Hallym University)H-Index: 27
view all 7 authors...
Chrysin, a natural flavonoid, is the main ingredient of many medicinal plants, which shows potent pharmacological properties. In the present study, the antinociceptive effects of chrysin were exami...
#1Shima Sadeghi-Soureh (Urmia University of Medical Sciences)H-Index: 1
#2Reza Jafari (Urmia University of Medical Sciences)H-Index: 2
Last. Younes Pilehvar-Soltanahmadi (Urmia University of Medical Sciences)H-Index: 1
view all 4 authors...
Abstract Recent reports imply that drug delivery approaches aimed to modulate the phenotypic and functional switching of macrophages towards anti-inflammatory (M2) phenotypes have a great regenerative potential in wound healing. Therefore, the present work was designed to reveal the effectiveness of a nanofiber (NF)-based drug delivery system incorporated with a natural immunomodulatory agent, Chrysin (CHR) to repolarize RAW264.7 macrophage cells from M1 to M2 phenotype. In this regard, CHR-poly...
#1F. N. Mbaoji (UNN: University of Nigeria, Nsukka)H-Index: 3
#2Akachukwu Marytheresa Onwuka (UNN: University of Nigeria, Nsukka)
Last. Lilian Eleje Okonta (UNN: University of Nigeria, Nsukka)
view all 6 authors...
Background. The stem bark decoction of Stemonocoleus micranthus Harms (Fabaceae) is most widely used traditionally as a remedy for various diseases such as malaria and boil. In this study, the anti-inflammatory and immunomodulatory activities of the methanol-dichloromethane extract (MDE) from the stem bark of the plant in rodents were evaluated. Methods. The carrageenan-induced rat paw oedema, cotton pellet-induced granuloma in rat, and xylene-induced ear oedema in mice were used to study the an...
The present study is an attempt to evaluate the in vitro anti-inflammatory and in silico anticancer potentials of the plant Cassia auriculata (CA). The aerial parts of CA were subjected to solvent extraction, and the extracts were fractionised by gas chromatography and mass spectrometry analysis for its phytochemical content. The antiinflammatory activity of the extracts were confirmed by the IC50 value of 125.02 microg/ml for red blood cell membrane stabilisation and 195.7 microg/ml for inhibit...
#1E. HalevasH-Index: 6
#2Barbara MavroidiH-Index: 3
Last. Maria PelecanouH-Index: 17
view all 8 authors...
Chemotherapeutic metal-based compounds are effective anticancer agents, however, their cytotoxic profile and significant side effects limit their wide application. Natural products and especially flavonoids are a prominent alternative source of anticancer agents that can be used as ligands for the generation of new bioactive complexes with metal ions of known‏ biochemical and pharmacological activities. Herein we present the synthesis and detailed structural and physicochemical characterization ...
Background Acute diarrhea is still a common and serious disease. The causes of acute diarrhea are very complicated. Therefore, we need to find a medicine to control diarrhea symptoms, save time for diagnosis of pathogens, and prevent drug abuse. Ellagic acid (EA), a natural polyphenol drug, has anti-diarrhea effects. However, the action mechanisms of EA for non-specific diarrhea have not been characterized.
#1Yu-Han Gui (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Li Liu (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Hou-Wen Lin (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 10 authors...
Abstract Two unique nitrogenous sesquiterpene quinone meroterpenoids, dysidinoid B (1) and dysicigyhone A (2), together with eight known analogues (3–10) were isolated and characterized from the marine sponge Dysidea septosa. Their structures with absolute configurations were established by a combination of extensive spectroscopic, electron circular dichroism (ECD) and single-crystal X-ray diffraction data analysis. Structurally, dysicigyhone A (2) possessed a unique benzo[d]oxazolidine-2-one un...
1 CitationsSource
#1Xuan Chen (Shanxi Medical University)H-Index: 8
#2Yanqin Zhang (Shanxi Medical University)H-Index: 2
Last. Dan Tie (Shanxi Medical University)
view all 9 authors...
Two proposed syringe membrane filter solid phase microextraction and syringe membrane filter liquid/solid phase microextraction, coupled separately with high performance liquid chromatography, were developed for simultaneous enrichment and determination of the trace level of flavonoids in traditional Chinese medicine. In syringe membrane filter solid phase microextraction, the membrane of syringe membrane filter was served as a solid adsorption film to adsorb target analytes. And in syringe memb...