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Biomedicine & Pharmacotherapy
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3.74
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Papers 10715
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Published on Dec 1, 2019in Biomedicine & Pharmacotherapy3.74
Chunfeng Li3
Estimated H-index: 3
,
Man Li , Yingwei Xue7
Estimated H-index: 7
Abstract Diosbulbin-B (DB) was the main compound of Dioscorea bulbifera L, which was widely used for cancer treatment in Asia. However, the hepatotoxicity induced by high-dose DB seriously limited its possibility using for gastric cancer (GC) treatment in clinic. In this study, we found that DB inhibited GC cells and hepatocytes cell viability in a dose- and time-dependent manner. Specifically, high-dose DB (50μM) significantly inhibited cell proliferation and promoted cell apoptosis, while low ...
Published on Dec 1, 2019in Biomedicine & Pharmacotherapy3.74
Abstract Long non-coding RNA (lncRNA) linc00152 has been recognized as an oncogenic lncRNA in various cancers. This study attempts to investigate the roles of linc00152 in the metastasis-related traits of infantile hemangioma (IH). Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 r...
Published on Dec 1, 2019in Biomedicine & Pharmacotherapy3.74
Xige Chen1
Estimated H-index: 1
,
Juan Gao1
Estimated H-index: 1
+ 2 AuthorsYingli Pan1
Estimated H-index: 1
Abstract Purpose The aim was to study the mechanism of LncRNA FOXD3-AS1 in cutaneous melanoma. Methods FOXD3-AS1 levels in 47 pairs of melanoma samples were detected. We used qRT-PCR to detect FOXD3-AS1, miR-325 and MAP3K2 expression in different staging samples and cutaneous melanoma cell lines. We used Kaplan-Meier curve to analyze survival rate in patients with FOXD3-AS1 high and low expression. Sh-FOXD3-AS1, miR-325, miR-325 inhibitor and oeMAP3K2 were transfected. The proliferation of A375 ...
Published on Dec 1, 2019in Biomedicine & Pharmacotherapy3.74
Tianyi Yu3
Estimated H-index: 3
(SJTU: Shanghai Jiao Tong University),
Dan Liu1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University)
+ 5 AuthorsYan Liu11
Estimated H-index: 11
(SJTU: Shanghai Jiao Tong University)
Abstract Background and purpose Dexmedetomidine (Dex) has been shown to elicit cardio-protective effects in sepsis. The aim of this study was to investigate the role of autophagy in the protective effects of Dex and its possible mechanism in vivo and vitro. Experimental approach 6-8-week-old male Wistar rats were performed cecal ligation puncture (CLP) and administered 0.9% saline (CLP group), 50 μg/kg Dex (Dex group), Dex plus chloroquine (20 mg/kg; Dex + CQ group), or 40 μg/kg methyllycaconiti...
Published on 2019in Biomedicine & Pharmacotherapy3.74
Paria Pashazadeh-Panahi2
Estimated H-index: 2
(Tabriz University of Medical Sciences),
Mohammad Hasanzadeh29
Estimated H-index: 29
(Tabriz University of Medical Sciences)
Abstract Biomedicine is inseparable part of medicine that play vital role in modern medical progress. Bioimaging, smart drug delivery, safe cancer therapy and personalized medicine are some important properties of this science. Pico technology as a next frontier in a scientific filed will revolutionized the scientist world ubiquitously. Extraordinary abilities of pico-particles will overcome convention obstacles and reveal spectacular impact on various scientific fields as well as biomedicine. F...
Published on Dec 1, 2019in Biomedicine & Pharmacotherapy3.74
Lingyan Wang (Kunming Medical University), Shumiao Tang (Kunming Medical University)+ 3 AuthorsJinqiao Qian1
Estimated H-index: 1
(Kunming Medical University)
Abstract Background Dexmedetomidine is widely used for perioperative and ICU patients. microRNAs (miRNAs) function as regulators of gene expression. The aim of the study was to assay expression profiling of microRNA in rat hearts following administration of dexmedetomidine. Methods In this study 6 rats were randomly divided into two groups (n = 3): dexmedetomidine group and control group. The rats of dexmedetomidine group were intraperitoneally given dexmedetomidine in a dose of 100 μg/kg wherea...
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