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Biomedicine & Pharmacotherapy
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#1YueJiao Wang (PRC: China Medical University (PRC))H-Index: 2
#2Lin-Xin Hou (PRC: China Medical University (PRC))H-Index: 3
Last. Ning Zhang (PRC: China Medical University (PRC))H-Index: 6
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Abstract Accumulating evidence suggests that miR-483−3p is implicated in maintaining biological properties in human cancers. However, its biological roles in rheumatoid arthritis (RA) remain unknown. miR-483−3p levels in synovial tissue samples and fibroblast-like synoviocytes (FLSs) were determined using quantitative real-time PCR. The CCK-8 assay and EdU staining were performed to assess cell proliferation in RA FLSs after transfection with miR-483−3p mimics or inhibitor. Flow cytometry with A...
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#1Chunyuan Wang (Dalian Medical University)H-Index: 1
#2Xianzong Meng (Radboud University Nijmegen)
Last. Laiyu Song (Dalian Medical University)H-Index: 2
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Abstract PM2.5, a main particulate air pollutant, poses a serious hazard to human health. The exposure to PM2.5 increases mortality and morbidity of many respiratory diseases such as asthma, chronic obstructive pulmonary diseases and even lung cancer. The contribution of reactive oxygen species (ROS) in the PM2.5-induced acute lung injury process was confirmed in our previous research, but the molecular mechanism based for it remains unclarified. In this research, ROS-induced lung injury after e...
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#1Ikrame Zeouk (Sidi Mohamed Ben Abdellah University)
#2Ines Sifaoui (ULL: University of La Laguna)H-Index: 11
Last. José E. Piñero (ULL: University of La Laguna)H-Index: 18
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Abstract Neglected tropical diseases such as leishmaniasis and American trypanosomiasis represent an increasing health problem. Current treatments are not satisfactory which remains an urgent need for novel, cheap and safe chemotherapies. In the course of our ongoing search for new potential anti-protozoal agents, this study aimed to perform a bio-guided fractionation of Inula viscosa (Asteraceae) using in vitro assays against three strains of Leishmania and Trypanosma genus. Eight known compoun...
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#1Guang-Xiao. Ni (Hebei Medical University)
#2Ce. Liang (Hebei University)
Last. Ya-li. Wang (Hebei University)
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Abstract Astragaloside IV (AST) as the main active ingredient of Astragalus membranaceus. Clinical and laboratory-based studies have demonstrated the effects of AST on cerebral protection and angiogenesis after ischemia stroke. In addition, several reports investigated the effect of AST on proliferation of neural stem cells. The current study was aimed to evaluate the influence of AST on neurogenesis in hippocampal dentate gyrus (DG) of MCAO rats and to explore the possible mechanisms. In this s...
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#1Gaojun WuH-Index: 3
#2Zhengxian WangH-Index: 3
Last. Zhouqing HuangH-Index: 11
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#1Shangying Ma (ZJNU: Zhejiang Chinese Medical University)
#2Xueyi Wang (ZJNU: Zhejiang Chinese Medical University)
Last. Chenghua Lou (ZJNU: Zhejiang Chinese Medical University)H-Index: 4
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Abstract Picrorhiza kurroa, the dried rhizome of Picrorhiza kurroa Royle ex Benth, is a famous Chinese herb that has been traditionally used in China. Picroside II (PII), a glycoside derivative, is the main bioactive constituent of Picrorhiza kurroa. In the past several decades, bioactive components from Picrorhiza kurroa have attracted the attention of researchers due to their promising therapeutic effects. A large number of studies have demonstrated the therapeutic potential of PII for the pre...
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#1Ke Ma (ZJNU: Zhejiang Chinese Medical University)H-Index: 1
#2Fan Zhao (Nantong University)H-Index: 1
Last. Bo-Dong Lv (ZJNU: Zhejiang Chinese Medical University)H-Index: 3
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Abstract Neurogenic erectile dysfunction (NED) is an inevitable postoperative disease of cavernous nerve injury which will lead to various pathophysiological changes in the corpus cavernosum and dorsal penile nerve caused by radical prostatectomy (RP). Although serval years of clinical application of HJIG I granules (HJIG), an innovative formulation, has demonstrated its reliable clinical efficacy against NED, the mechanism of HJIG remains unclear. This study aimed to assess the neuroprotective ...
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#1Weili LiuH-Index: 3
#2Lingling PuH-Index: 1
Last. Zhaoli ChenH-Index: 1
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Abstract Backgrounds Numerous studies have revealed that hypobaric hypoxia exposure elicited imbalance of homeostasis. However, the effects of intermittent hypobaric hypoxia (IHH) exposure on the female reproductive system have been rarely reported. This study aims to assess the effects of IHH on rat female reproductive system and explore the corresponding mechanism at the histological, endocrine and molecular levels. Methods The female rats were randomly divided into control and IHH groups. Mul...
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