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Biomedicine & Pharmacotherapy
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10797
Papers 10784
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#1Reem Al Alawi (Sultan Qaboos University)
Last.Younis Baqi (Sultan Qaboos University)H-Index: 25
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Abstract Date palm fruit (Phoenix dactylifera L.) is an endemic functional food, with great nutritional and economic importance due to its phytochemical compositions. The microenvironment of pancreatic cancer consists of cellular and acellular components, including fibroblasts, myofibroblasts, pancreatic stellate cells (PSCs), immune cells, blood vessels, extracellular matrix (ECM) and soluble proteins, such as cytokines and growth factors. The ECM represents a physical barrier that protects the...
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#1Chunfeng Li (HMU: Harbin Medical University)
#2Man Li (HMU: Harbin Medical University)
Last.Yingwei Xue (HMU: Harbin Medical University)
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Abstract Diosbulbin-B (DB) was the main compound of Dioscorea bulbifera L, which was widely used for cancer treatment in Asia. However, the hepatotoxicity induced by high-dose DB seriously limited its possibility using for gastric cancer (GC) treatment in clinic. In this study, we found that DB inhibited GC cells and hepatocytes cell viability in a dose- and time-dependent manner. Specifically, high-dose DB (50μM) significantly inhibited cell proliferation and promoted cell apoptosis, while low ...
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#1Jinli Wang (Nantong University)
#2Gaoxing Su (Nantong University)
Last.Bohua Chen (Nantong University)
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Abstract Afatinib (Afa), a second-generation irreversible epidermal growth factor inhibitor for the development of non-small cell lung cancer, has low bioavailability and adverse reactions. Nanoscaled drug delivery systems offer promising alternatives to address these defects and improve therapeutic outcomes. In the present study, a Tf contained, redox-sensitive ligand was synthesized and used for the preparation of afatinib loaded, Tf modified redox-sensitive lipid-polymer hybrid nanoparticles ...
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#1Saige Yin (Kunming Medical University)H-Index: 1
#2Ying Wang (State Ethnic Affairs Commission)H-Index: 4
Last.Xinwang Yang (Kunming Medical University)H-Index: 7
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Abstract With increasing demand, the development of new natural antioxidants has become a primary direction of scientific research. We previously identified a short gene-encoded peptide (OA-VI12) from Odorrana andersonii frog skin secretions that exerted direct scavenging capacity against free radicals, suggesting a possible function in protecting skin against photodamage caused by their high-altitude habitat. In the current research, we examined the effects of OA-VI12 on both UVB-irradiation an...
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#1Huan Zhou (Tianjin University of Traditional Chinese Medicine)
#2Bin Wang (Tianjin University of Traditional Chinese Medicine)
Last.Junping Zhang (Tianjin University of Traditional Chinese Medicine)H-Index: 2
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Abstract The occurrence of ischemic heart disease(IHD) is a multi-step chain process from potential risk factors to overt clinical diseases. Vascular cells, blood cells, cardiomyocytes and stem cells are all involved in the pathophysiological links via continual and polynary crosstalk. Exosomes,as powerful vectors for intercellular communication,have been a hotspot for basic and clinical research. Plenty of evidence has shown that exosomes largely participate in the evolution of IHD, including e...
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#1Nagla A. El-Shitany (Tanta University)H-Index: 8
#2Basma G. Eid (KAU: King Abdulaziz University)H-Index: 3
Abstract Cellular inflammation has been recognized as the leading factor in numerous diseases, causing either cell death, organ-specific damage, or genesis of different cancers. Icariin, a flavonol glucoside, extracted from Herba Epimedii, offers various pharmacological activities, including reducing inflammation and an antioxidant effect. We aimed to evaluate the anti-inflammatory mechanisms of icariin focussing on both HO-1/Nrf2 and NF-kB pathways. Acute inflammation was induced in rats via ca...
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#1Tianyi Yu (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Dan Liu (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last.Yan Liu (SJTU: Shanghai Jiao Tong University)H-Index: 9
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Abstract Background and purpose Dexmedetomidine (Dex) has been shown to elicit cardio-protective effects in sepsis. The aim of this study was to investigate the role of autophagy in the protective effects of Dex and its possible mechanism in vivo and vitro. Experimental approach 6-8-week-old male Wistar rats were performed cecal ligation puncture (CLP) and administered 0.9% saline (CLP group), 50 μg/kg Dex (Dex group), Dex plus chloroquine (20 mg/kg; Dex + CQ group), or 40 μg/kg methyllycaconiti...
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#1Abdul Hameed (CUI: COMSATS Institute of Information Technology)H-Index: 31
#2Sayed Ali Raza (KU: University of Karachi)H-Index: 4
Last.Rahman M. Hafizur (KU: University of Karachi)H-Index: 11
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Abstract Tambulin, a flavonol isolated from Zanthoxylum armatum, showed potent insulin secretory activity in our preliminary anti-diabetic screening. Here, we explored the insulin secretory mechanism(s) of tambulin focusing in glucose-dependent, KATP ‒ and Ca2+‒channels dependent, and cAMP-PKA pathways. Mice islets and MIN6 cells were incubated with tambulin in the presence of pharmacological agonists/antagonists and the secreted insulin was measured using mouse insulin ELISA kit. The intracellu...
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#1Xige ChenH-Index: 1
#2Juan GaoH-Index: 1
Last.Yingli PanH-Index: 1
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Abstract Purpose The aim was to study the mechanism of LncRNA FOXD3-AS1 in cutaneous melanoma. Methods FOXD3-AS1 levels in 47 pairs of melanoma samples were detected. We used qRT-PCR to detect FOXD3-AS1, miR-325 and MAP3K2 expression in different staging samples and cutaneous melanoma cell lines. We used Kaplan-Meier curve to analyze survival rate in patients with FOXD3-AS1 high and low expression. Sh-FOXD3-AS1, miR-325, miR-325 inhibitor and oeMAP3K2 were transfected. The proliferation of A375 ...
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Abstract Long non-coding RNA (lncRNA) linc00152 has been recognized as an oncogenic lncRNA in various cancers. This study attempts to investigate the roles of linc00152 in the metastasis-related traits of infantile hemangioma (IH). Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 r...
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Top fields of study
Apoptosis
Cancer research
Biochemistry
Diabetes mellitus
Biology