Original paper
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
Abstract
Development of an efficacious, non-addicting analgesic has been challenging. Discovery of novel mechanisms underlying addiction may present a solution. Here we target the neurokinin system, which is involved in both pain and addiction. Morphine exerts its rewarding actions, at least in part, by inhibiting GABAergic input onto substance P (SP) neurons in the ventral tegmental area (VTA), subsequently increasing SP release onto dopaminergic...
Paper Details
Title
Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential
Published Date
May 9, 2017
Journal
Volume
23
Issue
8
Pages
1745 - 1755
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Notes
History