Molecular Psychiatry
Papers 4328
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#1Chen Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 24
#2Xiao Xiao (KIZ: Kunming Institute of Zoology)H-Index: 10
Last. Ming Li (KIZ: Kunming Institute of Zoology)H-Index: 22
view all 4 authors...
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there are still remaining questions to answer. For example, discordance exists between BD heritability estimated with earlier epidemiological evidence and that calculated based on common GWAS variations. Where is the “missing heritability”? How can we explain the biology of the disease based on genetic findings? In this rev...
#1Laura Han (VU: VU University Amsterdam)H-Index: 3
#2Richard Dinga (Radboud University Nijmegen)H-Index: 2
Last. Klaus Berger (WWU: University of Münster)H-Index: 70
view all 146 authors...
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 yea...
#1Jonathan R. I. Coleman ('KCL': King's College London)H-Index: 15
#2Wouter J. Peyrot (VU: VU University Amsterdam)H-Index: 7
Last. S. Van der AuweraH-Index: 17
view all 26 authors...
#1Massimo Filippi (UniSR: Vita-Salute San Raffaele University)H-Index: 118
#2Silvia BasaiaH-Index: 6
Last. Vladana Markovic (University of Belgrade)H-Index: 6
view all 12 authors...
Longitudinal connectivity studies might guide our understanding of the underlying neurodegenerative processes. We report the results of a longitudinal study in patients at different stages of Parkinson’s disease (PD), who performed motor and non-motor evaluations and serial resting state (RS) functional MRI (fMRI). Cluster analysis was applied to demographic and clinical data of 146 PD patients to define disease subtypes. Brain network functional alterations were assessed at baseline in PD relat...
#1Benjamin Davidson (Sunnybrook Research Institute)H-Index: 1
#2Clement Hamani (Sunnybrook Research Institute)H-Index: 45
Last. Margaret A. RichterH-Index: 31
view all 14 authors...
Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common, often refractory, neuropsychiatric conditions for which new treatment approaches are urgently needed. Magnetic resonance-guided focused ultrasound (MRgFUS) is a novel surgical technique permitting incisionless ablative neurosurgery. We examined the safety profile, clinical response, and imaging correlates of MRgFUS bilateral anterior capsulotomy in patients with refractory obsessive compulsive disorder (OCD, N = ...
#1Sarah E Williams (Harvard University)
#2Robert G Mealer (Broad Institute)
Last. Richard D. Cummings (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 91
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Glycosylation, the enzymatic attachment of carbohydrates to proteins and lipids, regulates nearly all cellular processes and is critical in the development and function of the nervous system. Axon pathfinding, neurite outgrowth, synaptogenesis, neurotransmission, and many other neuronal processes are regulated by glycans. Over the past 25 years, studies analyzing post-mortem brain samples have found evidence of aberrant glycosylation in individuals with schizophrenia. Proteins involved in both e...
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#1Amanda J. Price (Johns Hopkins University)H-Index: 2
#2Andrew E. JaffeH-Index: 32
Last. Daniel R. WeinbergerH-Index: 162
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While a definitive understanding of schizophrenia etiology is far from current reality, an increasing body of evidence implicates perturbations in early development that alter the trajectory of brain maturation in this disorder, leading to abnormal function in early childhood and adulthood. This atypical development likely arises from an interaction of many brain cell types that follow distinct developmental paths. Because both cellular identity and development are governed by the transcriptome ...
#1Victor Benno Meyer-Rochow (University of Oulu)H-Index: 22
#2Tapani Hakko (OUH: Oulu University Hospital)
Last. Markku Timonen (University of Oulu)H-Index: 27
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Suicide data for this study were available for the period of March 1988 to June 2011, and involved 2111 male and 494 female victims from the Finnish province of Oulu. Data for lunar phases during that period were categorised into three groups: new moon ( 75% visible) and other times with values in between. Seasonal effects were controlled with definitions for winter (Nov, Dec, Jan), spring (Feb, Mar, Apr), summer (May, June, July), and autumn (Aug, Sep, Oct). Suicide occurrences during different...
#1Michael V. Lombardo (University of Cambridge)H-Index: 39
#1Harshmeena R. Sanghani (University of Oxford)
#2Aarti Jagannath (University of Oxford)H-Index: 14
Last. Sally A. Cowley (University of Oxford)H-Index: 26
view all 16 authors...
Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder remains elusive, but treatment with lithium continues as the benchmark pharmacotherapy, functioning as a potent mood stabilizer in most, but not all patients. Lithium is well documented to induce period lengthening and amplitude enhancement of the circadian clock. Based on this, w...
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