A Genetic Analysis of the Caenorhabditis elegans Detoxification Response
Abstract
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (Nuclear factor-erythroid-related factor 2, SKN-1 in Caenorhabditis elegans). Nrf2/SKN-1 activation promotes...
Paper Details
Title
A Genetic Analysis of the Caenorhabditis elegans Detoxification Response
Published Date
Jun 1, 2017
Journal
Volume
206
Issue
2
Pages
939 - 952
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