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#1Emily M. Adney (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#2Matthias T. Ochmann (Paul Ehrlich Institute)
Last.Jef D. Boeke (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 91
view all 10 authors...
Long Interspersed Nuclear Element-1 (LINE-1, L1) is the only autonomous active transposable element in the human genome. The L1- encoded proteins ORF1p and ORF2p enable the element to jump from one locus to another via a "copy and paste" mechanism. ORF1p is an RNA-binding protein and ORF2p has endonuclease and reverse transcriptase activities. The huge number of truncated L1 remnants in the human genome suggests that the host has likely evolved mechanisms to prevent full L1 replication and there...
#1Tiina Tamm (UT: University of Tartu)H-Index: 10
#2Ivan Kisly (UT: University of Tartu)H-Index: 2
Last.Jaanus Remme (UT: University of Tartu)H-Index: 21
view all 3 authors...
Ribosomes of Archaea and Eukarya share higher homology with each other than with bacterial ribosomes. For example, there is a set of 35 r-proteins that are specific only for archaeal and eukaryotic ribosomes. Three of these proteins, eL19, eL24 and eL41, participate in interactions between ribosomal subunits. The eukaryote-specific extensions of r-proteins eL19 and eL24 form two intersubunit bridges eB12 and eB13, which are present only in eukaryotic ribosomes. The third r-protein, eL41, forms b...
#1Yingjie Zhou (Zhejiang Wanli University)H-Index: 1
#2Wei Sun (Zhejiang Wanli University)H-Index: 3
Last.Chutian Ge (Zhejiang Wanli University)H-Index: 8
view all 7 authors...
Anti-mullerian hormone (Amh, or Mullerian-inhibiting substance, Mis), a member of TGF-β superfamily, as initiator or key regulator in sexual development has been well documented in some vertebrates, especially in fish. However, its functional role has not been identified yet in reptiles. Here we characterized the Amh gene in Chinese soft-shelled turtle Pelodiscus sinensis (P. sinensis), a typical reptilian species exhibiting ZZ/ZW sex chromosomes. The mRNA of Amh was initially expressed in male ...
#1Rebecca Keener (JHUSOM: Johns Hopkins University School of Medicine)
#2Carla Connelly (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 15
Last.Carol W. Greider (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 68
view all 3 authors...
Previous models suggested that regulation of telomere length in S. cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathways. We found that Rad53 mediates a Mec1 telomere length regulation pathway but is dispensable for T­­el1 telomere length regulation, whereas in the DNA damage response Rad53 is regulated by bot...
#1Asen Daskalov (University of California, Berkeley)H-Index: 2
#2Pierre Gladieux (University of Montpellier)H-Index: 1
Last.N. Louise Glass (LLNL: Lawrence Livermore National Laboratory)
view all 4 authors...
Non-self recognition following cell fusion between genetically distinct individuals of the same species in filamentous fungi often results in a programmed cell death (PCD) reaction, where the heterokaryotic fusion cell is compartmentalized and rapidly killed. The allorecognition process plays a key role as a defense mechanism that restricts genome exploitation, resource plundering and the spread of deleterious senescence plasmids and mycoviruses. Although a number of incompatibility systems have...
#1Marnin D. Wolfe (Cornell University)H-Index: 6
#2Guillaume J. Bauchet (Boyce Thompson Institute for Plant Research)H-Index: 1
Last.Jean-Luc Jannink (USDA: United States Department of Agriculture)H-Index: 48
view all 10 authors...
Introgression of alleles from wild relatives has often been adaptive in plant breeding. However, the significance of historical hybridization events in modern breeding is often not clear. Cassava (Manihot esculenta) is among the most important staple foods in the world, sustaining hundreds of millions of people in the tropics, especially in sub-Saharan Africa. Widespread genotyping makes cassava a model for clonally-propagated root and tuber crops in the developing world and provides an opportun...
#1Sarah Piccirillo (UMKC: University of Missouri–Kansas City)H-Index: 7
#2Abbigail H. McCune (UMKC: University of Missouri–Kansas City)
Last.Saul M. Honigberg (UMKC: University of Missouri–Kansas City)H-Index: 10
view all 8 authors...
Under conditions in which budding yeast form colonies and then undergo meiosis/sporulation, the resulting colonies are organized such that a sharply-defined layer of meiotic cells overlays a layer of unsporulated cells termed "feeder cells". This differentiation pattern requires activation of both the Rlm1/cell-wall integrity pathway and the Rim101/alkaline-response pathway. In the current study, we analyzed the connection between these two signaling pathways in regulating colony development by ...
#1Jason Chien (University of Gothenburg)
#2Fred W. Wolf (UCM: University of California, Merced)H-Index: 21
Last.Catarina Mörck (University of Gothenburg)H-Index: 9
view all 6 authors...
Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells promote larval development, however, remains a mystery. In screens for mutations that bypass CAN function, we identified the gene kin-29, which encodes a member of the Salt-Inducible Kinase (SIK) family and a component of a conserved pathway tha...
#1Randall J. Wisser (UD: University of Delaware)H-Index: 17
#2Zhou Fang (NCSU: North Carolina State University)H-Index: 7
Last.Arnel R. Hallauer (Iowa State University)H-Index: 29
view all 12 authors...
Understanding the evolutionary capacity of populations to adapt to novel environments is one of the major pursuits in genetics. Moreover, for plant breeding, maladaptation is the foremost barrier to capitalizing on intraspecific variation in order to develop new breeds for future climate scenarios in agriculture. Using a unique study design, we simultaneously dissected the population and quantitative genomic basis of short-term evolution in a tropical landrace of maize that was translocated to a...
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