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#1Martin R. Silic (Purdue University)
#2Qiuyu Wu (Purdue University)H-Index: 2
Last. GuangJun Zhang (Purdue University)H-Index: 12
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The roles of bioelectric signaling in developmental patterning remain largely unknown, although recent work has implicated bioelectric signals in cellular processes such as proliferation and migration. Here, we report a mutation in the inwardly rectifying potassium channel (kir) gene, kcnj13/kir7.1, that causes elongation of the fins in the zebrafish insertional mutant Dhi2059. A viral DNA insertion into the noncoding region of kcnj13 results in transient activation and ectopic expression of kcn...
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#1Behailu Birhanu Aklilu (A&M: Texas A&M University)H-Index: 1
#2François Peurois (University of Paris)
Last. Lauren Sampson (A&M: Texas A&M University)
view all 12 authors...
Replication protein A (RPA) is essential for many facets of DNA metabolism. The RPA gene family expanded in Arabidopsis thaliana with five phylogenetically distinct RPA1 subunits (RPA1A-E), two RPA2 (RPA2A and B), and two RPA3 (RPA3A and B). RPA1 paralogs exhibit partial redundancy and functional specialization in DNA replication (RPA1B and RPA1D), repair (RPA1C and RPA1E), and meiotic recombination (RPA1A and RPA1C). Here we show that RPA subunits also differentially impact telomere length set ...
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#1Sophie J. Walton (California Institute of Technology)
#2Han Wang (California Institute of Technology)H-Index: 6
Last. Paul W. Sternberg (California Institute of Technology)H-Index: 91
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To mitigate the deleterious effects of temperature increases on cellular organization and proteotoxicity, organisms have developed mechanisms to respond to heat stress. In eukaryotes, HSF1 is the master regulator of the heat shock transcriptional response, but the heat shock response pathway is not yet fully understood. From a forward genetic screen for suppressors of heat shock induced gene expression in Caenorhabditis elegans, we found a new allele of hsf-1 that alters its DNA-binding domain, ...
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#2Zuzana MajtánováH-Index: 6
Last. Karel Janko (University of Ostrava)H-Index: 19
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#1Sibel Kucukyildirim (Hacettepe University)H-Index: 6
#2Megan G. Behringer (ASU: Arizona State University)H-Index: 6
Last. Michael Lynch (ASU: Arizona State University)H-Index: 102
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#1Michael L. Nonet (WashU: Washington University in St. Louis)H-Index: 40
The application of CRISPR technology has greatly facilitated the creation of transgenic Caenorhabditis elegans lines. However, methods to insert multi-kilobase DNA constructs remain laborious even with these advances. Here I describe a new approach for introducing large DNA constructs into the C. elegans genome at specific sites using a combination of Flp and Cre recombinases. The system utilizes specialized integrated landing sites that express GFP ubiquitously flanked by single loxP, FRT and F...
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#1Maxwell A. Tracy (UW: University of Washington)
#2Mitchell B. Lee (UW: University of Washington)H-Index: 3
Last. Niloufar Ghodsian (UW: University of Washington)H-Index: 1
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Heterozygous mutations affecting DNA polymerase (Pol) exonuclease domains and homozygous inactivation of mismatch repair (MMR) each generate "mutator" phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against further mutation accumulation. In haploid yeast, simultaneous defects in polymerase proofreading and MMR select for "antimutator" mutants that suppress t...
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#1Elizabeth C. Barretto (U of C: University of Calgary)H-Index: 1
#2Danielle M. Polan (U of C: University of Calgary)
Last. Savraj S. Grewal (U of C: University of Calgary)H-Index: 10
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#1Katie Reding (UMD: University of Maryland, College Park)H-Index: 2
#2Leslie Pick (UMD: University of Maryland, College Park)H-Index: 23
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#1Xinjun Zhang (UCLA: University of California, Los Angeles)
#2Bernard Y. Kim (Stanford University)H-Index: 7
Last. Emilia Huerta-Sanchez (Brown University)H-Index: 18
view all 4 authors...
Admixture with archaic hominins has altered the landscape of genomic variation in modern human populations. Several gene regions have been previously identified as candidates of adaptive introgression (AI) that facilitated human adaptation to specific environments. However, simulation-based studies have suggested that population genetic processes other than adaptive mutations, such as heterosis from recessive deleterious variants private to populations before admixture, can also lead to patterns...
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