Original paper
Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
Abstract
Microhomology (MH) flanking a DNA double-strand break (DSB) drives chromosomal rearrangements but its role in mutagenesis has not yet been analyzed. Here we determined the mutation frequency of a URA3 reporter gene placed at multiple locations distal to a DSB, which is flanked by different sizes (15-, 18-, or 203-bp) of direct repeat sequences for efficient repair in budding yeast. Induction of a DSB accumulates mutations in the reporter gene...
Paper Details
Title
Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
Published Date
Apr 18, 2017
Journal
Volume
13
Issue
4
Pages
e1006714 - e1006714
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Notes
History