Original paper

Human haematopoietic stem cell lineage commitment is a continuous process

Volume: 19, Issue: 4, Pages: 271 - 281
Published: Mar 20, 2017
Abstract
Blood formation is believed to occur through stepwise progression of haematopoietic stem cells (HSCs) following a tree-like hierarchy of oligo-, bi- and unipotent progenitors. However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment....
Paper Details
Title
Human haematopoietic stem cell lineage commitment is a continuous process
Published Date
Mar 20, 2017
Volume
19
Issue
4
Pages
271 - 281
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