Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells

Significance At the initial stage of carcinogenesis, transformation occurs in a single cell within the epithelium. However, it is not clearly understood what happens at the interface between the newly emerging transformed cells and the surrounding normal epithelial cells. Here, using mammalian cell culture and zebrafish embryo systems, we demonstrate that Rab5, an important regulator of endocytosis, is accumulated and that endocytosis is...