Takeshi Maruyama
Hokkaido University
28Publications
14H-index
1,583Citations
Publications 28
Newest
Published on Dec 1, 2018in Scientific Reports 4.12
Nobuhiro Kasai2
Estimated H-index: 2
(Hokkaido University),
Ailijiang Kadeer2
Estimated H-index: 2
(Hokkaido University)
+ 4 AuthorsYasuyuki Fujita25
Estimated H-index: 25
(Hokkaido University)
Recent studies have revealed that newly emerging RasV12-transformed cells are often apically extruded from the epithelial layer. During this cancer preventive process, cytoskeletal proteins plectin and Epithelial Protein Lost In Neoplasm (EPLIN) are accumulated in RasV12 cells that are surrounded by normal cells, which positively regulate the apical elimination of transformed cells. However, the downstream regulators of the plectin-EPLIN complex remain to be identified. In this study, we have fo...
2 Citations Source Cite
Published on Nov 1, 2018in Genes to Cells 2.05
Mikio Takagi (Hokkaido University), Masaya Ikegawa16
Estimated H-index: 16
(Doshisha University)
+ 5 AuthorsYasuyuki Fujita25
Estimated H-index: 25
(Hokkaido University)
At the initial stage of carcinogenesis, transformation occurs in single cells within the epithelium. Recent studies have revealed that the newly emerging transformed cells are often apically eliminated from epithelial tissues. However, the underlying molecular mechanisms of this cancer preventive phenomenon still remain elusive. In this study, we first demonstrate that myosin-II accumulates in Src-transformed cells when they are surrounded by normal epithelial cells. Knock-down of the heavy chai...
Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Ailijiang Kadeer2
Estimated H-index: 2
(Hokkaido University),
Takeshi Maruyama14
Estimated H-index: 14
(Hokkaido University)
+ 7 AuthorsYasuyuki Fujita25
Estimated H-index: 25
(Hokkaido University)
4 Citations Source Cite
Sayaka Saitoh3
Estimated H-index: 3
(Hokkaido University),
Takeshi Maruyama14
Estimated H-index: 14
(Hokkaido University)
+ 11 AuthorsSusumu Ishikawa13
Estimated H-index: 13
(Hokkaido University)
Newly emerging transformed cells are often eliminated from epithelial tissues. Recent studies have revealed that this cancer-preventive process involves the interaction with the surrounding normal epithelial cells; however, the molecular mechanisms underlying this phenomenon remain largely unknown. In this study, using mammalian cell culture and zebrafish embryo systems, we have elucidated the functional involvement of endocytosis in the elimination of RasV12-transformed cells. First, we show th...
8 Citations Source Cite
Novalia Pishesha6
Estimated H-index: 6
(Massachusetts Institute of Technology),
Angelina M. Bilate18
Estimated H-index: 18
(Massachusetts Institute of Technology)
+ 10 AuthorsStephanie K. Dougan24
Estimated H-index: 24
(Massachusetts Institute of Technology)
Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or therapeutically to induce antigen-specific tolerance might overcome these obstacles. Here we use the transpeptidase sortase to covalently attach disease-associated autoantigens to genetically engineered and to unmodified red blood cells as a means of in...
23 Citations Source Cite
Published on Oct 1, 2017in Current Opinion in Cell Biology 10.02
Takeshi Maruyama14
Estimated H-index: 14
(Hokkaido University),
Yasuyuki Fujita25
Estimated H-index: 25
(Hokkaido University)
In the multi-cellular community, cells with different properties often compete with each other for survival and space. This process is named cell competition and was originally discovered in Drosophila . Recent studies have revealed that comparable phenomena also occur in mammals under various physiological and pathological conditions. Within the epithelium, normal cells often recognize the presence of the neighboring transformed cells and actively eliminate them from the epithelium; a process t...
15 Citations Source Cite
Published on May 1, 2017in Nature Cell Biology 19.06
Shunsuke Kon11
Estimated H-index: 11
(Hokkaido University),
Kojiro Ishibashi1
Estimated H-index: 1
(Hokkaido University)
+ 36 AuthorsYuta Yako6
Estimated H-index: 6
(Hokkaido University)
Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.
22 Citations Source Cite
Published on Nov 8, 2016in The Molecular Biology Society of Japan
Takeshi Maruyama14
Estimated H-index: 14
(Hokkaido University),
Sayuri Iijima (Hokkaido University), Yasuyuki Fujita25
Estimated H-index: 25
(Hokkaido University)
Published on Nov 1, 2015in Cell Reports 8.03
Hisae Kadowaki17
Estimated H-index: 17
(University of Tokyo),
Atsushi Nagai8
Estimated H-index: 8
(Tokyo Medical and Dental University)
+ 10 AuthorsTakashi Sato15
Estimated H-index: 15
(Kumamoto University)
Cells possess ER quality control systems to adapt to ER stress and maintain their function. ER-stress-induced pre-emptive quality control (ER pQC) selectively degrades ER proteins via translocational attenuation during ER stress. However, the molecular mechanism underlying this process remains unclear. Here, we find that most newly synthesized endogenous transthyretin proteins are rerouted to the cytosol without cleavage of the signal peptide, resulting in proteasomal degradation in hepatocytes ...
14 Citations Source Cite
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