CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein
Abstract
Previous works using human tripronuclear zygotes suggested that the clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system could be a tool in correcting disease-causing mutations. However, whether this system was applicable in normal human (dual pronuclear, 2PN) zygotes was unclear. Here we demonstrate that CRISPR/Cas9 is also effective as a gene-editing tool in human 2PN zygotes. By injection of Cas9 protein complexed...
Paper Details
Title
CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein
Published Date
Mar 1, 2017
Volume
292
Issue
3
Pages
525 - 533
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