An overview of chemical constituents from Alpinia species in the last six decades

Published on Jan 1, 2017in RSC Advances3.049
· DOI :10.1039/C6RA27830B
Xiao-Ni Ma1
Estimated H-index: 1
(SOA: State Oceanic Administration),
Chun-Lan Xie6
Estimated H-index: 6
(SOA: State Oceanic Administration)
+ 2 AuthorsXian-Wen Yang24
Estimated H-index: 24
(SOA: State Oceanic Administration)
Alpinia species is one of the most important genera of the Zingiberaceae family. In Asia, they have been widely used as food and traditional medicines for centuries. This review focuses on their chemical constituents and their relevant biological activities with 252 references covering from 1955 to 2015. In total, 544 compounds were isolated from 35 Alpinia species. The major ones are terpenoids (207) and diarylheptanoids (143). The crude extracts and identified compounds exhibited a broad spectrum of bioactivities including antiemetic, antiulcer, antibacterial, anti-inflammatory, anti-amnesic, anticancer, etc.
  • References (209)
  • Citations (5)
📖 Papers frequently viewed together
36 Citations
4 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Chinthamony Arul Raj (Karpagam University)H-Index: 5
#2Paramasivam Ragavendran (Karpagam University)H-Index: 6
Last. Velliyur Kanniappan Gopalakrishnan (Karpagam University)H-Index: 15
view all 6 authors...
Objective To evaluate the enzymatic and non-enzymatic antioxidants of leaf extract from Alpinia purpurata.
2 CitationsSource
#1Eric Wei Chiang Chan (UCSI University)H-Index: 12
#2Siu Kuin Wong (Monash University)H-Index: 9
In this review, the phytochemistry and pharmacology of two ornamental gingers, Hedychium coronarium (butterfly ginger) and Alpinia purpurata (red ginger), are updated, and their botany and uses are described. Flowers of H. coronarium are large, showy, white, yellow or white with a yellow centre and highly fragrant. Inflorescences of A. purpurata are erect spikes with attractive red or pink bracts. Phytochemical investigations on the rhizomes of H. coronarium generated research interest globally....
11 CitationsSource
#1de Sousa DpH-Index: 36
Last. Roberto AndreatiniH-Index: 29
view all 4 authors...
The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium ...
34 CitationsSource
#1Chuan-Pu Shen (CPU: China Pharmaceutical University)H-Index: 3
#2Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 24
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 36
view all 4 authors...
Two pairs of enantiomers of flavonoid oligomers (1a and 1b, 2a and 2b) along with one known chalcone (3) were isolated from the rhizomes of Alpinia platychilus. Their structures were elucidated on the basis of spectroscopic data (MS and 1D/2D NMR). The absolute configurations of the flavonoid oligomers were established by their ECD spectra. Separation of the enantiomeric mixtures (1a and 1b, 2a and 2b) was achieved on a chiral column using hexane:isopropyl alcohol:ethanol (7:2:1) as eluents. The...
3 CitationsSource
Dihydro-5,6-dehydrokavain (DDK) is the major and most promising component of the tropical plant Alpinia zerumbet (shell ginger), a species of the ginger family Zingiberaceae. Alpinia zerumbet is known for its human use as a traditional herbal medicine, food, and dietary supplement. With its α-lactone ring, DDK belongs to the large chemical group of kavalactones, which are also found in kava (Piper methysticum), another herbal medicine; DDK is characterized by a double-bond linkage at positions 5...
11 CitationsSource
#1Wan-Qiu Yang (Kunming University)H-Index: 2
#2Yuan GaoH-Index: 1
Last. Fei WangH-Index: 24
view all 5 authors...
Three novel chalcones bearing a long-chain alkylphenol, galanganones A–C (1–3), were isolated from the rhizomes of Alpinia galanga. Their structures were elucidated by extensive spectroscopic analysis including 2D NMR experiments. Compounds 1–3 represent the first examples of long-chain alkylphenol-coupled chalcone.
2 CitationsSource
#1Rachsawan Mongkol (Chula: Chulalongkorn University)H-Index: 2
#2Warinthorn Chavasiri (Chula: Chulalongkorn University)H-Index: 21
Last. Masanori Morimoto (Kindai University)H-Index: 9
view all 5 authors...
The management of weeds and diseases that are caused by phytopathogenic fungi is important for preventing the loss of agricultural products. The aim of the present study was to identify phytotoxic and antiphytopathogenic agents from the Thai Alpinia galanga rhizome. Extracts of the dried rhizomes of A. galanga (Zingiberaceae) were separated and tested for phytotoxic activity against lettuce (Lactuca sativa L. cv. Great Lakes) and Italian ryegrass (Lolium multiflorum Lam. cv. Wasefudou) and for a...
3 CitationsSource
#1Pham Thi Be Tu (Kadai: Kagoshima University)H-Index: 5
#2Jamnian Chompoo (Kasetsart University)H-Index: 8
Last. Shinkichi Tawata (University of the Ryukyus)H-Index: 24
view all 3 authors...
10 CitationsSource
#1Qiang‐Ming Li (CPU: China Pharmaceutical University)H-Index: 4
#2Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 24
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 14
view all 4 authors...
A new sesquiterpenoid, 1, and three new diterpenoids, 3-5, along with five known compounds, 2 and 6-9, were isolated from rhizomes of Alpinia japonica. The structures of the new compounds were determined as (1R,4R,6S,7S,9S)-4α-hydroxy-1,9-peroxybisabola-2,10-diene (1), methyl (12E)-16-oxolabda-8(17),12-dien-15-oate (3), (12R)-15-ethoxy-12-hydroxylabda-8(17),13(14)-dien-16,15-olide (4), and methyl (11E)-14,15,16-trinorlabda-8(17),11-dien-13-oate (5) by means of spectroscopic data. The absolute co...
6 CitationsSource
#1Qiao-Hui Zeng (SCUT: South China University of Technology)H-Index: 3
#2Chuan-Li Lu (SCUT: South China University of Technology)H-Index: 9
Last. Jian-Guo Jiang (SCUT: South China University of Technology)H-Index: 29
view all 4 authors...
This study was carried out to isolate ingredients from the seeds of a Chinese spice (Alpinia galangal) and to evaluate their cytotoxic activity on cancer cell lines. Isolation and purification of the phytochemical constituents were conducted using silica gel, Sephadex LH-20 and ODS columns. After extraction using 95% ethanol, the total extracts were re-extracted, resulting in petroleum ether (PE), ethyl acetate (EA) and water fractions, respectively. Activity tests showed that the EA fraction ex...
7 CitationsSource
Cited By5
#1Divya Lakshmanan (Pondicherry University)H-Index: 1
#2Adhikesavan Harikrishnan (Pondicherry University)H-Index: 3
Last. Kadirvelu Jeevaratnam (Pondicherry University)H-Index: 8
view all 5 authors...
AIM: The study was aimed at purifying the active principle from Alpinia officinarum rhizomes responsible for inhibition of swarming motility of Pseudomonas aeruginosa and analysing the mechanism of action. METHODS AND RESULTS: The active compound from methanol extract of A. officinarum was purified by silica gel column chromatography followed by elution from Amberlite resin. The compound 1-(3,5-dihydroxyphenyl)-2-(methylamino)ethan-1-one, inhibited swarming motility at 12.5 microg ml(-1) . This ...
#1Ching-Ying Kuo (KMU: Kaohsiung Medical University)H-Index: 3
#2Teng-Song Weng (KMU: Kaohsiung Medical University)H-Index: 1
Last. Hui-Chun Wang (NSYSU: National Sun Yat-sen University)H-Index: 6
view all 7 authors...
Recent advances in mammography screening, chemotherapy, and adjuvant treatment modalities have improved the survival rate of women with breast cancer. Nevertheless, the breast tumor with metastatic...
#1Yasir Osman Ali Abdalla (UM: University of Malaya)H-Index: 1
#2Shaik Nyamathulla (UM: University of Malaya)H-Index: 4
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 10
view all 7 authors...
Abstract 1′-S-1′-acetoxychavicol acetate (ACA) has been previously reported to reduce tumor volume in nude mice, at an effective dose of 1.56 mg/kg body weight. However, the detailed toxicological profile for ACA has not yet been performed. Herein, we investigated the toxicity of intravenous administration of ACA in male and female Sprague-Dawley rats, both acutely (with single doses of 2.00, 4.00 and 6.66 mg/kg body weight, for 14 days), and sub-acutely (with weekly injections of 0.66, 1.33, an...
3 CitationsSource
#1Takashi Kamada (UMS: Universiti Malaysia Sabah)H-Index: 7
#2Shean-Yeaw Ng (UMS: Universiti Malaysia Sabah)H-Index: 1
Last. Charles Santhanaraju Vairappan (UMS: Universiti Malaysia Sabah)H-Index: 21
view all 4 authors...
The longevity of the population in the Okinawa Islands of Japan has been ascribed to genetic factors and the traditional Okinawa cuisine, which is low in calories and high in plant content. This diet includes shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae). Due to its local popularity, Alpinia zerumbet has become the subject of a good deal of study at the University of the Ryukyus in Okinawa. Personal local experience and review of the literature...
14 CitationsSource
#1Richard D. McLane (Northern Kentucky University)H-Index: 1
Last. Amber J. Onorato (Northern Kentucky University)H-Index: 1
view all 8 authors...
Abstract Prostaglandin E2 (PGE2) is a lipid mediator of inflammation and its inhibition has become a popular drug target due to its harmful physiological roles. Diarylheptanoids are one class of compounds that have shown successful inhibition of PGE2. This paper reports the synthesis and PGE2 inhibitory activity of a series of analogues of a naturally occurring diarylheptanoid. The most efficacious compounds were examined for dose-dependent PGE2 inhibition. Among several promising compounds, the...
3 CitationsSource