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Chun-Lan Xie
State Oceanic Administration
ChemistryDeep seaFungusBiochemistryStereochemistry
26Publications
6H-index
94Citations
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Publications 29
Newest
Last. Xian-Wen Yang (SOA: State Oceanic Administration)H-Index: 24
view all 9 authors...
A unique polyketide cladosporactone A ( 1 ), along with eight known compounds ( 2 - 9 ) were isolated from the deep-sea-derived Cladosporium cladosporioides . The structure of 1 was established by spectroscopic analyses, and the absolute configuration was clarified by the theoretical ECD calculation. Compound 1 is the first member of polyketide with 7-methylisochromen-3-one skeleton.
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#1Siwen Niu (Ontario Ministry of Natural Resources)H-Index: 8
#1Siwen Niu (Ontario Ministry of Natural Resources)H-Index: 1
Last. Xian-Wen Yang (Ontario Ministry of Natural Resources)H-Index: 24
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Eight unprecedent diterpenoids, botryotins A–H (1–8), were obtained from Botryotinia fuckeliana. They represent three novel carbon skeletons with 6/6/5/5 (1), 6/6/5/6 (2–6), and 6/6/6/5 (7 and 8) tetracyclic scaffolds. Their structures were determined by detailed spectroscopic analysis and chemical derivatization as well as quantum chemical calculation of the ECD and OR data. Botryotin A (1) exhibited a moderate antiallergic effect (IC50 = 0.2 mM). A plausible biosynthetic pathway for 1–8 was pr...
1 CitationsSource
#1Jin-Mei Xia (Ontario Ministry of Natural Resources)H-Index: 3
#2Zi Miao (Ontario Ministry of Natural Resources)H-Index: 1
Last. Xian-Wen Yang (Ontario Ministry of Natural Resources)H-Index: 24
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Starfishes produce various structurally unique secondary metabolites with diverse biological activities. This review is an update summary of the new compounds and their bioactivities from starfish (the Asteroidea Class) with 71 references covering from January 2007 to December 2018. During this period, 216 new compounds were obtained from 36 species. The chemical constituents are mostly steroids, steroidal glycosides, and gangliosides. These components have been found to possess various bioactiv...
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#1Siwen NiuH-Index: 1
#2Guizhen PengH-Index: 1
Last. Xian-Wen Yang (SOA: State Oceanic Administration)H-Index: 24
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A new pimarane diterpenoid, named botryopimarene A (1), was discovered from the fungus Botryotinia fuckeliana MCCC 3 A00494 isolated from the deep-sea water, together with ten known compounds. The planar structure of 1 was established based on the extensive spectroscopic analyses. The absolute configurations of tricyclic system in 1 were resolved by the theoretical ECD calculation, while the 15,16-diol moiety in the side chain was resolved by the Mo2 (OAc)4 -induced ECD spectrum. Compound 1, fea...
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#1Chun-Lan Xie (SOA: State Oceanic Administration)H-Index: 6
#2Jin-Mei Xia (SOA: State Oceanic Administration)H-Index: 3
Last. Xian-Wen Yang (SOA: State Oceanic Administration)H-Index: 24
view all 10 authors...
Two new (1, 2) and one known (3) meroterpenoids were isolated from the deep-sea-derived fungus Penicillium allii-sativi. The relative structures of new compounds were determined on the basis of extensive analysis of the NMR and MS data. And the absolute configurations were established by ECD calculations. Andrastone A (1) was a rare andrastin bearing an unusual cyclopentan-1,3-dione. It showed selectively antiproliferative effect against HepG2 tumor cells with an IC50 value of 7.8 μM. Mechanism ...
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#1Chun-Lan Xie (Ha Tai: Xiamen University)H-Index: 6
#2Renzhi Chen (Ha Tai: Xiamen University)H-Index: 2
Last. Xian-Wen Yang (Ontario Ministry of Natural Resources)H-Index: 24
view all 8 authors...
An intriguing cage-like polyhemiketal, nesteretal A (1), was isolated from the coral-derived actinomycete Nesterenkonia halobia. Its structure was established by extensive spectroscopic and computational methods. Nesteretal A is a highly oxygenated compound featuring an unprecedented 5/5/5/5 tetracyclic scaffold. A possible biosynthetic pathway of 1 from naturally occurring diacetyl was proposed. Compound 1 showed a weak retinoid X receptor-α (RXRα) transcriptional activation effect.
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#1Siwen Niu (Ontario Ministry of Natural Resources)H-Index: 1
#2Chun-Lan Xie (Ontario Ministry of Natural Resources)H-Index: 6
Last. Xian-Wen Yang (Ontario Ministry of Natural Resources)H-Index: 24
view all 7 authors...
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#1Siwen NiuH-Index: 1
#2Chun-Lan XieH-Index: 6
Last. Xian-Wen YangH-Index: 24
view all 7 authors...
Source
#1Cui-Ping XingH-Index: 1
#2Chun-Lan XieH-Index: 6
Last. Xian-Wen YangH-Index: 24
view all 8 authors...
Four new (penigrisacids A–D, 1–4) and one known (5) carotane sesquiterpenoids were isolated from the deep-sea-derived fungus Penicillium griseofulvum, along with four known compounds (6–9). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Co...
2 CitationsSource
#1Siwen Niu (Ontario Ministry of Natural Resources)H-Index: 1
#2Jin-Mei Xia (Ontario Ministry of Natural Resources)H-Index: 3
Last. Xian-Wen Yang (Ontario Ministry of Natural Resources)H-Index: 24
view all 10 authors...
Aphidicolin, a potent DNA polymerase α inhibitor, has been explored in clinical trials for the treatment of cancer. So far, about 300 modified aphidicolins have been discovered. However, none have shown a stronger effect. Herein, we report 71 new (aphidicolins A1–A71, 1–71) and eight known (72–79) aphidicolin congeners from Botryotinia fuckeliana MCCC 3A00494, a fungus isolated from the western Pacific Ocean (−5572 m). The structures of 1–71 were determined through extensive spectroscopic analys...
2 CitationsSource
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