The effects of synthetic cannabinoids on executive function

Published on Apr 1, 2017in Psychopharmacology3.424
· DOI :10.1007/s00213-017-4546-4
K Cohen1
Estimated H-index: 1
(ELTE: Eötvös Loránd University),
Máté Kapitány-Fövény10
Estimated H-index: 10
(Semmelweis University)
+ 4 AuthorsAviv Weinstein27
Estimated H-index: 27
Background and aims There is a growing use of novel psychoactive substances (NPSs) including synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis but the new synthetic cannabinoids are more potent and dangerous and their use has resulted in various adverse effects. The purpose of the study was to assess whether persistent use of synthetic cannabinoids is associating with impairments of executive function in chronic users.
  • References (69)
  • Citations (17)
📖 Papers frequently viewed together
118 Citations
264 Citations
80 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Francesca M. Filbey (UTD: University of Texas at Dallas)H-Index: 29
#2Tim McQueeny (UTD: University of Texas at Dallas)H-Index: 3
Last. Ariel Ketcherside (UTD: University of Texas at Dallas)H-Index: 6
view all 5 authors...
Abstract Combined use of marijuana (MJ) and tobacco is highly prevalent in today’s population. Individual use of either substance is linked to structural brain changes and altered cognitive function, especially with consistent reports of hippocampal volume deficits and poorer memory performance. However, the combined effects of MJ and tobacco on hippocampal structure and on learning and memory processes remain unknown. In this study, we examined both the individual and combined effects of MJ and...
32 CitationsSource
Introduction and Aims Synthetic cannabinoid dependence and withdrawal are not well described in the literature. We aimed to report on the characteristics and treatment course of clients attending a detoxification service for support with synthetic cannabinoid withdrawal in Auckland, New Zealand. Design and Methods A retrospective audit of electronic and paper files for clients presenting for treatment in association with problematic synthetic cannabinoid use between May 2013 and May 2014 was con...
43 CitationsSource
#1Rachael I. RosnerH-Index: 1
294 CitationsSource
#1Justine Renard (Paris V: Paris Descartes University)H-Index: 3
#2Marie-Odile Krebs (Paris V: Paris Descartes University)H-Index: 48
Last. Thérèse M. Jay (Paris V: Paris Descartes University)H-Index: 1
view all 4 authors...
Marijuana is the most widely used illicit drug among adolescents and young adults. Unique cognitive, emotional, and social changes occur during this critical period of development from childhood into adulthood. The adolescent brain is in a state of transition and differs from the adult brain with respect to both anatomy (e.g., neuronal connections and morphology) and neurochemistry (e.g., dopamine, GABA, and glutamate). These changes are thought to support the emergence of adult cerebral process...
60 CitationsSource
#1Marisol S. Castaneto (UMB: University of Maryland, Baltimore)H-Index: 12
#2David A. Gorelick (UMB: University of Maryland, Baltimore)H-Index: 50
Last. Marilyn A. Huestis (NIDA: National Institute on Drug Abuse)H-Index: 67
view all 6 authors...
264 CitationsSource
#1Taylor HatchardH-Index: 7
#2Peter A. FriedH-Index: 31
Last. Andra M. Smith (U of O: University of Ottawa)H-Index: 19
view all 5 authors...
There is a growing body of evidence that marijuana use during adolescence, a critical period in neurocognitive development, may have lasting detrimental impact on executive functioning. The Ottawa Prenatal Prospective Study (OPPS) has followed participants over 20 years, from birth to young adulthood, and has collected data on potentially confounding lifestyle variables, such as prenatal drug exposure and current drug use. In the present study, we report the effects of heavy adolescent onset mar...
11 CitationsSource
#1Matthijs G. BossongH-Index: 21
#2Gerry JagerH-Index: 24
Last. Paul AllenH-Index: 48
view all 4 authors...
Smoking cannabis produces a diverse range of effects, including impairments in learning and memory. These effects are exerted through action on the endocannabinoid system, which suggests involvement of this system in human cognition. Learning and memory deficits are core symptoms of psychiatric and neurological disorders such as schizophrenia and Alzheimer’s disease, and may also be related to endocannabinoid dysfunction in these disorders. However, before new research can focus on potential tre...
39 CitationsSource
BACKGROUND - Synthetic cannabinoids in smoking mixtures (such as Spice) or as raw powder are sold for recreational use as an alternative to herbal cannabis (hashish and marijuana). Although clinical case studies have documented an array of side effects, there is also information available at Internet based drug discussion forums. AIM - Our study investigates experiences of side effects from use of synthetic cannabinoids, as described and anonymously shared on Swedish online discussion forums. ME...
24 CitationsSource
#1Balapal S. Basavarajappa (Columbia University)H-Index: 33
#2Shivakumar Subbanna (Nathan Kline Institute for Psychiatric Research)H-Index: 13
Recently, synthetic cannabinoids have been sprayed onto plant material, which is subsequently packaged and sold as “Spice” or “K2” to mimic the effects of marijuana. A recent report identified several synthetic additives in samples of “Spice/K2”, including JWH-081, a synthetic ligand for the cannabinoid receptor 1 (CB1). The deleterious effects of JWH-081 on brain function are not known, particularly on CB1 signaling, synaptic plasticity, learning and memory. Here, we evaluated the effects of JW...
35 CitationsSource
Twelve cases of suspected impaired driving are discussed in which the drivers who subsequently tested positive for synthetic cannabinoid drugs underwent a psychophysical assessment. The attitude of the drivers was described as cooperative and relaxed, speech was slow and slurred and coordination was poor. Pulse and blood pressure were generally elevated. Horizontal gaze nystagmus was assessed in nine of the subjects, but was present in only two. The most consistent indicator was a marked lack of...
48 CitationsSource
Cited By17
#1Vera AlvesH-Index: 15
#2João GonçalvesH-Index: 4
Last. José S. CâmaraH-Index: 36
view all 5 authors...
The word “cannabinoid” refers to every chemical substance, regardless of structure or origin, that joins the cannabinoid receptors of the body and brain and that have similar effects to those produ...
#1Koby Cohen (Ariel University)H-Index: 8
#2Shiri Rosenzweig (Ariel University)
Last. Aviv Weinstein (Ariel University)H-Index: 27
view all 6 authors...
Objective Chronic use of synthetic cannabinoids (SCs) has been associated with a wide range of negative consequences for health including psychotic and affective disturbances. Accumulating evidence indicates that cannabinoids use may be a risk factor for schizophrenia, and chronic natural cannabis users score higher than non-users on measures of schizotypal personality traits. However, little is known regarding the personality characteristics of SC users, especially in comparison with recreation...
#2Serenella Tolomeo (NUS: National University of Singapore)H-Index: 2
Last. Alex Baldacchino (St And: University of St Andrews)H-Index: 18
view all 4 authors...
Abstract Cannabis is currently the most used illicit substance in the world with a global widespread distribution. Although its acute neurocognitive effects on human behaviour have been reported, there is a lack of robust analysis investigating the link, if any, between chronic cannabis use and neurocognitive function. A systematic review of the literature was conducted in order to identify relevant studies published from 2010 to 2019. A meta-analysis was performed on 13 selected studies testing...
1 CitationsSource
#1Koby Cohen (Ariel University)H-Index: 8
#2Abraham WeizmanH-Index: 50
Last. Aviv Weinstein (Ariel University)H-Index: 27
view all 3 authors...
: Recreational and chronic cannabis use has been associated with a range of acute and chronic effects including; anti-nociceptive actions, anxiety, depression, psychotic symptoms and neurocognitive impairments. The mechanisms underlying cannabinoid-based drugs effects are not fully known but given the neuro-modulatory functions of the endocannabinoid system, it seems likely that agonistic activity at the cannabinoid type-1 receptors (CB1 ) might modulate the functions of other neurotransmitter s...
3 CitationsSource
Abstract Purpose Health concerns around cannabis (marijuana) use have focused on the possible relationship with psychosis and lower airway health, however; the effect of cannabis smoking on upper airway health has received less attention. The aim of this study is to investigate difference between exclusive tobacco cigarettes smoking compared with tobacco plus cannabis smoking regarding severity of chronic rhinosinusitis (CRS). Material and methods A prospective cross-sectional study with two gro...
#1Kirsten E. Smith (UK: University of Kentucky)H-Index: 3
#2Michele Staton (UK: University of Kentucky)H-Index: 19
AbstractBackground: Over the past decade, availability and use of novel psychoactive substances such as synthetic cannabinoid receptor agonists (SCRA) have proliferated globally. However, the preva...
#1Lucien Rochat (University of Geneva)H-Index: 20
#2Pierre Maurage (UCL: Université catholique de Louvain)H-Index: 32
Last. Joël Billieux (UNIL: University of Lausanne)H-Index: 39
view all 4 authors...
Decision-making impairments play a pivotal role in the emergence and maintenance of addictive disorders. However, a sound conceptualization of decision making as an umbrella construct, encompassing its cognitive, affective, motivational, and physiological subcomponents, is still lacking. This prevents an efficient evaluation of the heterogeneity of decision-making impairments and the development of tailored treatment. This paper thus unfolds the various processes involved in decision making by a...
5 CitationsSource
#1Hina Akram (UCL: University College London)H-Index: 1
#2Claire Mokrysz (UCL: University College London)H-Index: 10
Last. H. Valerie Curran (UCL: University College London)H-Index: 34
view all 3 authors...
Background:Synthetic cannabinoids are, typically, full agonists at the cannabinoid CB1 receptor, and therefore considerably more potent than natural cannabis and may have correspondingly more serio...
2 CitationsSource
#1Sai Krishna Tikka (AIIMS: All India Institute of Medical Sciences)H-Index: 2
#2Deepak Cyril D'Souza (Yale University)H-Index: 37
According to the exogenous cannabinoid hypothesis, exposure to cannabis and cannabinoid receptor (CB1R) agonists (henceforth referred to as “cannabinoids”) is associated with a number of psychosis outcomes. The high rates and earlier onset of cannabis use, the legalization of “medical” marijuana (cannabis) and recreational cannabis use in some states, the increasing availability and use of edible cannabinoid products and highly potent synthetic cannabinoids (e.g., Spice and K-2), the increasing ...
2 CitationsSource