Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins of Zika virus protects both mice and rhesus macaques against infection and elicits rapid and long-lasting neutralizing antibody responses. Public health efforts to combat Zika virus disease are hampered by lack of a safe and efficient vaccine. Drew Weissman and colleagues report the...