Review paper
Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences
Abstract
Following the discovery that the amyloid precursor protein (APP) is the source of β-amyloid peptides (Aβ) that accumulate in Alzheimer's disease (AD), structural analyses suggested that the holoprotein resembles a transmembrane receptor. Initial studies using reconstituted membranes demonstrated that APP can directly interact with the heterotrimeric G protein Gαo (but not other G proteins) via an evolutionarily G protein-binding motif in its...
Paper Details
Title
Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences
Published Date
Jan 31, 2017
Volume
10
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