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Frontiers in Molecular Neuroscience
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The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated. The glycine- and GABA-induced chloride current (IGly and IGly) were measured in isolated pyramidal neurons of the rat hippocampus and isolated rat cerebellar Purkinje cells, correspondingly, using the patch-clamp technique. Our results demonstrate that all the nine neurost...
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Phosphorylation-dependent peptidyl-prolyl cis-trans isomerization plays key roles in cell cycle progression, the pathogenesis of cancer, and age-related neurodegeneration. Most of our knowledge about the role of phosphorylation-dependent peptidyl-prolyl cis-trans isomerization and the enzyme catalyzing this reaction, the peptidyl-prolyl isomerase (Pin1), is largely limited to proteins not present in neurons. Only a handful of examples have shown that phosphorylation-dependent peptidyl-prolyl cis...
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#1W. Scott Young (NIH: National Institutes of Health)
#2June Song (NIH: National Institutes of Health)
Oxytocin, acting through the oxytocin receptor (Oxtr) in the periphery, is best known for its roles in regulating parturition and lactation. However, it is also now known to possess a number of important social functions within the central nervous system, including social preference, memory and aggression, that vary to different degrees in different species. The Oxtr is found in both excitatory and inhibitory neurons within the brain and research is focusing on how, for example, activation of th...
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#1Thomas K. Karikari (Warw.: University of Warwick)H-Index: 7
#2Rachel Thomas (Warw.: University of Warwick)
Last. Kevin G. Moffat (Warw.: University of Warwick)H-Index: 13
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Mutations in the MAPT gene can lead to disease-associated variants of tau. However, the pathological mechanisms behind these genetic tauopathies are poorly understood. Here, we characterized the aggregation stages and conformational changes of tau C291R, a recently described MAPT mutation with potential pathogenic functions. The C291R variant of the tau four-repeat domain (tau-K18; a functional fragment with increased aggregation propensity compared to the full-length protein), aggregated into a...
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#1Jary Y. Delgado (U of C: University of Chicago)H-Index: 2
#2Duncan L. Nall (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
Last. Paul R. Selvin (UIUC: University of Illinois at Urbana–Champaign)H-Index: 53
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The postsynaptic density protein 95 (PSD-95) plays a central role in excitatory synapse development and synaptic plasticity. Phosphorylation of the N-terminus of PSD-95 at threonine 19 (T19) and serine 25 (S25) decreases PSD-95 stability at synapses; however, a molecular mechanism linking PSD-95 phosphorylation to altered synaptic stability is lacking. Here, we show that phosphorylation of T19/S25 recruits the phosphorylation-dependent peptidyl-prolyl cis-trans isomerase (Pin1) and reduces the p...
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#1Antonio MonacoH-Index: 1
#2Alessandro Fraldi (University of Naples Federico II)H-Index: 21
Many neurodegenerative conditions are characterized by the deposition of protein aggregates (mainly amyloid-like) in the central nervous system (CNS). In post-mitotic CNS cells protein aggregation causes citotoxicity by interfering with various cellular functions. Mutations in different genes may directly cause protein aggregation. However, genetic factors together with aging may contribute to the onset of protein aggregation also by affecting cellular degradative functions, in particular the au...
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#1Rong-Zheng Mu (MUC: Minzu University of China)H-Index: 1
#2Shuang Liu (MUC: Minzu University of China)
Last. Yao-Jiang Huang (Harvard University)H-Index: 1
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BACKGROUND Studies suggest that neuron-specific enolase (NSE) levels in the cerebrospinal fluid (CSF) and serum play an important role in childhood epilepsy. However, these investigations remain controversial due to inconsistent clinical results. The present study aimed to quantitatively summarise and assess whether CSF and serum NSE levels are associated with epilepsy in children. METHODS A systematic search of the Harvard Hollis+, Clinicaltrials, Open Grey, China National Knowledge Infrastruct...
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Top fields of study
Neuroscience
Biochemistry
Biology
Cell biology
Synaptic plasticity