doi.org/10.12688/f1000research.9503.1
Review paper

Genetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities

Terri H. Beaty
79
,
Mary L. Marazita
71
,
Elizabeth J. Leslie
26
F1000Research
Volume: 5, Pages: 2800 - 2800
Published: Nov 30, 2016
Abstract
Orofacial clefts include cleft lip (CL), cleft palate (CP), and cleft lip and palate (CLP), which combined represent the largest group of craniofacial malformations in humans with an overall prevalence of one per 1,000 live births. Each of these birth defects shows strong familial aggregation, suggesting a major genetic component to their etiology. Genetic studies of orofacial clefts extend back centuries, but it has proven difficult to...
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Paper Details
Title
Genetic factors influencing risk to orofacial clefts: today’s challenges and tomorrow’s opportunities
DOI
doi.org/10.12688/f1000research.9503.1
Published Date
Nov 30, 2016
Journal
F1000Research
Volume
5
Pages
2800 - 2800
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