Terri H. Beaty
Johns Hopkins University
Publications 350
#1Nandita Mukhopadhyay (University of Pittsburgh)H-Index: 7
#2Madison Bishop (Emory University)
Last.Mary L. Marazita (University of Pittsburgh)H-Index: 55
view all 19 authors...
Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create a significant public health burden. The majority of OFCs are non-syndromic, and the genetic etiology of non-syndromic OFCs is only partially determined. Here, we analyze whole genome sequence (WGS) data for association with risk of OFCs in European and Colombian families selected from a multicenter family-based OFC study. This is the first large-scale WGS study of OFC in parent–offspring trios, a...
#1Nicolas Vince (French Institute of Health and Medical Research)H-Index: 8
#2Sophie Limou (French Institute of Health and Medical Research)H-Index: 17
Last.Sameer Chavan (University of Colorado Denver)H-Index: 3
view all 32 authors...
Abstract Background Asthma is a complex chronic inflammatory disease of the airways. Association studies between HLA and asthma were first reported in the 1970’s, and yet, the precise role of HLA alleles in asthma is not fully understood. Numerous genome-wide association studies were recently conducted on asthma, but were always limited to simple genetic markers (SNPs) and not complex HLA gene polymorphisms (alleles/haplotypes), therefore not capturing the biological relevance of this complex lo...
#1Stephen Milne (UBC: University of British Columbia)H-Index: 2
#2Xuan Li (UBC: University of British Columbia)H-Index: 5
Last.Ma'en Obeidat (UBC: University of British Columbia)H-Index: 20
view all 12 authors...
Background: There are currently no robust biomarkers of chronic obstructive pulmonary disease (COPD) risk or progression. Club cell secretory protein-16 (CC-16) is associated with the clinical expression of COPD. We aimed to determine if there is a causal effect of serum CC-16 level on COPD risk and/or progression using Mendelian randomisation (MR) analysis. Methods: We performed a genome-wide association meta-analysis for serum CC-16 in two COPD cohorts (Lung Health Study [LHS], n=3,850 and ECL...
#1Andrey Ziyatdinov (Harvard University)H-Index: 7
#2Margaret M. Parker (Brigham and Women's Hospital)H-Index: 17
Last.Hugues Aschard (Harvard University)H-Index: 21
view all 7 authors...
Admixture mapping has led to the discovery of many genes associated with differential disease risk by ancestry, highlighting the importance of ancestry-based approaches to association studies. However, the potential of admixture mapping in deciphering the interplay between genes and environment exposures has been seldom explored. Here we performed a genome-wide screening of local ancestry–smoking interactions for five spirometric lung function phenotypes in 3300 African Americans from the COPDGe...
#1Priyadarshini Kachroo (Brigham and Women's Hospital)H-Index: 4
#2Julian Hecker (Harvard University)H-Index: 2
Last.Sebastian ZoellnerH-Index: 3
view all 351 authors...
ABSTRACT Background Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based ‘Genetic Epidemiology of Asthma in Costa Rica’ study. Asthma affection ...
#1Ma'en ObeidatH-Index: 20
#2Alen FaizH-Index: 8
Last.Don D. SinH-Index: 67
view all 16 authors...
Inhaled corticosteroids (ICS) are widely prescribed for patients with chronic obstructive pulmonary disease (COPD), yet have variable outcomes and adverse reactions, which may be genetically determined. The primary aim of the study was to identify the genetic determinants for forced expiratory volume in 1 s (FEV1) changes related to ICS therapy. In the Lung Health Study (LHS)-2, 1116 COPD patients were randomised to the ICS triamcinolone acetonide (n=559) or placebo (n=557) with spirometry perfo...
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 26
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 65 authors...
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find ...
3 CitationsSource
#1Meher Preethi Boorgula (University of Colorado Denver)H-Index: 9
#2Margaret A. Taub (Johns Hopkins University)H-Index: 18
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 21 authors...
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH−, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+...
#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Caapa (University of Colorado Denver)H-Index: 1
Last.Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 66 authors...
1 CitationsSource
#1Woori Kim (Johns Hopkins University)
#2Michael H. Cho (Brigham and Women's Hospital)H-Index: 34
Last.Terri H. Beaty (Johns Hopkins University)H-Index: 65
view all 8 authors...
Background Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS) have identified multiple genetic factors associated with cross-sectional measures of quantitative emphysema, but the genetic determinants of longitudinal change in quantitative measures of emphysema remain largely unknown. Our study aims to identify genetic variants associated w...