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Mary L. Marazita
University of Pittsburgh
302Publications
55H-index
11.2kCitations
Publications 306
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Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create a significant public health burden. The majority of OFCs are non-syndromic, and the genetic etiology of non-syndromic OFCs is only partially determined. Here, we analyze whole genome sequence (WGS) data for association with risk of OFCs in European and Colombian families selected from a multicenter family-based OFC study. This is the first large-scale WGS study of OFC in parent–offspring trios, a...
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#1Ekaterina OrlovaH-Index: 4
#2Jenna C. CarlsonH-Index: 9
Last.John R. Shaffer (University of Pittsburgh)H-Index: 25
view all 9 authors...
Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously.
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#1Dzemila Sero (Katholieke Universiteit Leuven)H-Index: 1
#2Arslan A Zaidi (PSU: Pennsylvania State University)H-Index: 6
Last.Peter ClaesH-Index: 22
view all 12 authors...
Facial recognition from DNA refers to the identification or verification of unidentified biological material against facial images with known identity. One approach to establish the identity of unidentified biological material is to predict the face from DNA, and subsequently to match against facial images. However, DNA phenotyping of the human face remains challenging. Here, another proof of concept to biometric authentication is established by using multiple face-to-DNA classifiers, each class...
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#1Xinmin Liu (SSI: Statens Serum Institut)H-Index: 16
#2Dorte Helenius (Lundbeck)H-Index: 2
Last.Bjarke Feenstra (SSI: Statens Serum Institut)H-Index: 34
view all 74 authors...
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10−14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than ...
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#1Dmitry Shungin (Umeå University)H-Index: 23
#2Simon Haworth (UoB: University of Bristol)H-Index: 5
Last.Ingegerd Johansson (Umeå University)H-Index: 62
view all 38 authors...
Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched...
3 CitationsSource
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#1Daniel W. McNeil (WVU: West Virginia University)H-Index: 35
#2Cameron L. Randall (UW: University of Washington)H-Index: 6
Last.Mary L. Marazita (University of Pittsburgh)H-Index: 55
view all 7 authors...
1 CitationsSource
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#1Camden P. Bay (Brigham and Women's Hospital)
#2Steven M. Levy (UI: University of Iowa)H-Index: 51
Last.Trudy L. Burns (UI: University of Iowa)H-Index: 45
view all 7 authors...
Abstract The foundation for osteoporosis risk is, in part, established during childhood, adolescence, and young adulthood, all periods of development when bone mass is acquired rapidly. The relative quantity of bone mass accrued is influenced by both lifestyle and genetic factors, although the genetic component is not yet well understood. The purpose of this study was to use a genome-wide association (GWA) analysis to discover single nucleotide polymorphisms (SNPs) associated with: (1) the sex-s...
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#1Nandita Mukhopadhyay (University of Pittsburgh)H-Index: 7
#2Madison Bishop (Emory University)
Last.Mary L. Marazita (University of Pittsburgh)H-Index: 55
view all 19 authors...
Orofacial clefts (OFCs) are one of the most common birth defects worldwide and create a significant health burden. The majority of OFCs are non-syndromic, and the genetic component has been only partially determined. Here, we analyze whole genome sequence (WGS) data for association with risk of OFCs in European and Colombian families selected from a multicenter family-based OFC study. Part of the Gabriella Miller Kids First Pediatric Research Program, this is the first large-scale WGS study of O...
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