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Effects of the 5-HT1A receptor agonists buspirone and 8-OH-DPAT on pupil size in common marmosets.

Published on Jun 1, 2017in Behavioural Pharmacology1.788
· DOI :10.1097/FBP.0000000000000275
Manato Kotani4
Estimated H-index: 4
,
Naoko Urushino1
Estimated H-index: 1
+ 2 AuthorsKazuhito Ikeda6
Estimated H-index: 6
Abstract
As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents
  • References (19)
  • Citations (4)
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References19
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#1Manato KotaniH-Index: 4
#2Akihiko KiyoshiH-Index: 5
Last. Kazuhito IkedaH-Index: 6
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Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] ; [2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animal...
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#1Satoko BabaH-Index: 2
#2Takeshi MuraiH-Index: 6
Last. Kazuhito IkedaH-Index: 6
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Abstract Previous pilot clinical studies have shown that the serotonin 5-HT 1A receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. In the present study, we evaluated the cognitive efficacy of tandospirone, given alone or in combination with the antipsychotic blonanserin, risperidone or haloperidol, on executive function in marmosets using the object retrieval with detour (ORD) task. Treatment with tandospirone alone at 20 and 40 mg/kg increase...
10 CitationsSource
#1Kate M. Chitty (USYD: University of Sydney)H-Index: 10
#2Jim Lagopoulos (USYD: University of Sydney)H-Index: 40
Last. Daniel F. Hermens (USYD: University of Sydney)H-Index: 40
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Background: Comorbid risky alcohol use in bipolar disorder (BD) is recognized for its high prevalence and clinical relevance, though understanding of its neurobiological underpinning is limited. The N-methyl-D-aspartate (NMDA) receptor has recognized alterations in BD and is a major site of ethanol’s effects in the brain. The present study aimed to examine the NMDA receptor system in adolescents and young adults with BD by evaluating the longitudinal changes in a robust marker of NMDA function, ...
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#1Linda M. Rorick-Kehn (Eli Lilly and Company)H-Index: 17
#2Jennifer Witcher (Eli Lilly and Company)H-Index: 12
Last. Conrad J. Wong (Eli Lilly and Company)H-Index: 9
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Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression. The kappaopioid receptor (KOR) antagonist, LY2456302, exhibits ~30-fold higher affinity for KOR over mu opioid receptors (MOR), which is the next closest identified pharmacology. Here, we determined KOR pharmacological selectivity of LY2456302 by assessing MOR antagonism using translational pupillometry in rats and humans. In rats, morphine-induced mydriasis was completely blocked by ...
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#1Jude F. Mitchell (UCSD: University of California, San Diego)H-Index: 18
#2John H. Reynolds (Salk Institute for Biological Studies)H-Index: 31
Last. Cory T. Miller (UCSD: University of California, San Diego)H-Index: 22
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The common marmoset (Callithrix jacchus), a small-bodied New World primate, offers several advantages to complement vision research in larger primates. Studies in the anesthetized marmoset have detailed the anatomy and physiology of their visual system (Rosa et al., 2009) while studies of auditory and vocal processing have established their utility for awake and behaving neurophysiological investigations (Lu et al., 2001a,b; Eliades and Wang, 2008a,b; Osmanski and Wang, 2011; Remington et al., 2...
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#1Vassilis Koudas (UoC: University of Crete)H-Index: 2
#2Alexandra Nikolaou (UoC: University of Crete)H-Index: 2
Last. Panos Bitsios (UoC: University of Crete)H-Index: 37
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Rationale The human pupil may be a suitable physiological test system for the assessment of excessive daytime sleepiness (EDS), but pupillometric assessment could be confounded by medication for comorbid hypertension and mood disorders.
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Objective BAY 63-9044 is a new full 5-HT1A-agonist with functional dopamine agonist properties aimed for the treatment of Parkinson’s disease. This first-in-man study investigated the pharmacodynamics, safety and tolerability as well as the pharmacokinetics of BAY 63-9044 in a randomized, single-blind, placebo-controlled group-comparison dose escalation study.
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#1Yongxin Yu (OU: University of Oklahoma)H-Index: 7
#2Andrew G. Ramage (UCL: University College London)H-Index: 29
Last. Michael C. Koss (OU: University of Oklahoma)H-Index: 17
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Serotonin (5-HT)1A receptor agonists have been reported to produce mydriasis in mice, and miosis in rabbits and humans. However, the underlying mechanisms for this action are unclear. This study was undertaken in an attempt to explore the mechanism by which 5-HT1A receptors are involved in the modulation of pupillary size in pentobarbital-anesthetized rats. Intravenous administration of the 5-HT1A receptor agonist, (2R)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT; 0.003–3 ...
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#1Robert A. Myers (BMS: Bristol-Myers Squibb)H-Index: 5
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Last. Nicholas J. Lodge (BMS: Bristol-Myers Squibb)H-Index: 21
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Aims To examine the effects of 1-(2-pyrimidinyl)-piperazine (1-PP), a buspirone metabolite, on bladder function in vivo. Methods Micturition reflexes in the rat were evaluated in two models of bladder function; a constant infusion model employing 0.5% acetic acid and an isovolumic model. Results In the constant infusion model, 1-PP (0.14–1.32 mg/kg) dose-dependently and significantly decreased the number of bladder contractions measured during a 30 min recording period, with little effect on the...
8 CitationsSource
#1M. A. Phillips (University of Nottingham)H-Index: 7
#2Elemer Szabadi (University of Nottingham)H-Index: 38
Last. C. M. Bradshaw (University of Nottingham)H-Index: 41
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We investigated the effects of two 5-HT1A receptor agonists, buspirone and lesopitron, upon pupil size in human volunteers at an ambient luminance level of 32 Cd m72 and in darkness. Pupil diameter was monitored with a binocular infrared television pupillometer, before and after the administration of treatments for 4 h at 20-min intervals. Two experiments were conducted. In Experiment 1, 14 healthy male volunteers participated in seven weekly sessions, each associated with the ingestion of one c...
11 CitationsSource
Cited By4
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#1Silke Pfitzer (Murdoch University)H-Index: 2
#2A. Woodward (University of Melbourne)H-Index: 3
Last. M. Laurence (Murdoch University)H-Index: 7
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To determine the bioavailability and pharmacokinetic properties of the serotonin 5-HT1A receptor agonist R-8-OH-DPAT in goats, and 0.1 mg kg−1 R-8-OH-DPAT hydrobromide was administered intramuscularly (i.m.) and intravenously (i.v.) to six goats in a two-phase cross-over design experiment. Venous blood samples were collected from the jugular vein 2, 5, 10, 15, 20, 30, 40 and 60 min following treatment and analysed by liquid chromatography tandem mass spectrometry. Bioavailability and pharmacokin...
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#1Elemer Szabadi (University of Nottingham)H-Index: 38
Pupil diameter reflects the balance between opposing sympathetic and parasympathetic outputs to the iris. Pupil dilation is mediated by a sympathetic output acting in opposition to parasympathetically mediated pupil constriction. While light stimulates the parasympathetic output, giving rise to the light reflex, it has a dual effect on the sympathetic output: it can both inhibit and stimulate it. Light-inhibited and light-stimulated sympathetic pathways (LISPs and LSSPs) mediate the opposite eff...
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Abstract The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety lead-compound, our group designed, synthesized, and investigated the effects of a new piperazine compound, namely, LQFM104, on the behavior of mice. Male albino Swiss mice were treated with LQFM1...
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#1Manato KotaniH-Index: 4
#2Kohei ShimonoH-Index: 1
Last. Kazuhito IkedaH-Index: 6
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Abstract Eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. Eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (ASDs). Interestingly, the same eye tracking systems have been used to directly compare face scanning patterns in some non-human primates to those in human. Thus, eye tracking is expected to be a useful translational technique for investigating not onl...
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