Kazuhito Ikeda
Dainippon Sumitomo Pharma Co., Ltd.
Publications 24
#1Manato KotaniH-Index: 4
#2Kohei ShimonoH-Index: 1
Last.Kazuhito IkedaH-Index: 5
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Abstract Eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. Eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (ASDs). Interestingly, the same eye tracking systems have been used to directly compare face scanning patterns in some non-human primates to those in human. Thus, eye tracking is expected to be a useful translational technique for investigating not onl...
Abstract Antagonism of the dopamine D 3 receptor is considered a promising strategy for the treatment of cognitive impairment associated with schizophrenia. We have previously reported that the atypical antipsychotic blonanserin, a dopamine D 2 /D 3 and serotonin 5-HT 2A receptor antagonist, highly occupies dopamine D 3 receptors at its antipsychotic dose range in rats. In the present study, we evaluated the effects of blonanserin on executive function in common marmosets using the object retrie...
Abstract Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] , [2] . Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets ( Callithrix jacchus ) have recently attracted a great deal of attention as suitable experim...
#1Shunsuke NakazawaH-Index: 2
#2Takeshi MuraiH-Index: 5
Last.Kazuhito IkedaH-Index: 5
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Rationale Growing evidence suggests that dopamine D4 receptors (D4Rs) are involved in controlling executive functions. We have previously demonstrated that Ro 10-5824, a D4R partial agonist, improves the performance of common marmosets in the object retrieval detour (ORD) task. However, the neural mechanisms underlying this improvement are unknown.
#1Satoko BabaH-Index: 2
#2Takeshi MuraiH-Index: 5
Last.Kazuhito IkedaH-Index: 5
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Abstract Previous pilot clinical studies have shown that the serotonin 5-HT 1A receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. In the present study, we evaluated the cognitive efficacy of tandospirone, given alone or in combination with the antipsychotic blonanserin, risperidone or haloperidol, on executive function in marmosets using the object retrieval with detour (ORD) task. Treatment with tandospirone alone at 20 and 40 mg/kg increase...