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Kazuhito Ikeda
Dainippon Sumitomo Pharma Co., Ltd.
EndocrinologyPsychologyLurasidoneAgonistDopamine
23Publications
6H-index
108Citations
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Publications 19
Newest
#1Takeshi EnomotoH-Index: 7
Last. Kazuhito IkedaH-Index: 6
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In our drug discovery program, we identified a novel orally available and brain-penetrant phosphodiesterase (PDE) 1 inhibitor, 3-methyl-7-(tetrahydro-2H-pyran-4-yl)-2-{[trans-4-(trifluoromethyl)cyclohexyl]-methoxy}imidazo[5,1-f][1,2,4]triazin-4(3H)-one (DSR-141562). In the present study, we characterized the preclinical profile of DSR-141562. This compound has preferential selectivity for predominantly brain-expressed PDE1B over other PDE1 family members, and high selectivity for the PDE1 family...
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#1Takeshi EnomotoH-Index: 7
#2Naho Konoike (Primate Research Institute)H-Index: 5
Last. Kazuhito IkedaH-Index: 6
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1 CitationsSource
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#1Manato KotaniH-Index: 4
#2Kohei ShimonoH-Index: 1
Last. Kazuhito IkedaH-Index: 6
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Abstract Eye tracking systems are used to investigate eyes position and gaze patterns presumed as eye contact in humans. Eye contact is a useful biomarker of social communication and known to be deficient in patients with autism spectrum disorders (ASDs). Interestingly, the same eye tracking systems have been used to directly compare face scanning patterns in some non-human primates to those in human. Thus, eye tracking is expected to be a useful translational technique for investigating not onl...
7 CitationsSource
#1Manato KotaniH-Index: 4
#2Naoko UrushinoH-Index: 1
Last. Kazuhito IkedaH-Index: 6
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As pupil size is affected by psychotropic drugs in all mammals, it has been used as a well-established clinical indicator for the preclinical and clinical development of novel drugs. It has been reported that activation of the serotonin (5-HT)1A receptor differently affects pupil response in rodents
4 CitationsSource
#1Manato KotaniH-Index: 4
#2Takeshi EnomotoH-Index: 7
Last. Kazuhito IkedaH-Index: 6
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Abstract Antagonism of the dopamine D 3 receptor is considered a promising strategy for the treatment of cognitive impairment associated with schizophrenia. We have previously reported that the atypical antipsychotic blonanserin, a dopamine D 2 /D 3 and serotonin 5-HT 2A receptor antagonist, highly occupies dopamine D 3 receptors at its antipsychotic dose range in rats. In the present study, we evaluated the effects of blonanserin on executive function in common marmosets using the object retrie...
4 CitationsSource
#1Manato KotaniH-Index: 4
#2Akihiko KiyoshiH-Index: 4
Last. Kazuhito IkedaH-Index: 6
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Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] ; [2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animal...
11 CitationsSource
#1Satoko BabaH-Index: 2
#2Takeshi MuraiH-Index: 5
Last. Kazuhito IkedaH-Index: 6
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Abstract Previous pilot clinical studies have shown that the serotonin 5-HT 1A receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. In the present study, we evaluated the cognitive efficacy of tandospirone, given alone or in combination with the antipsychotic blonanserin, risperidone or haloperidol, on executive function in marmosets using the object retrieval with detour (ORD) task. Treatment with tandospirone alone at 20 and 40 mg/kg increase...
10 CitationsSource
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