Trypanosoma bruceimetabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion

Significance The parasite Trypanosoma brucei causes African sleeping sickness. This disease, which lacks effective treatments, affects millions of humans and livestock in sub-Saharan Africa. This paper reveals a mechanism by which the parasite can evade our immune response. Indolepyruvate is a metabolite produced by the parasite and it manipulates the immune cells, called macrophages, preventing them from becoming fully active. The selective...