Original paper
Trypanosoma bruceimetabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion
Abstract
Significance The parasite Trypanosoma brucei causes African sleeping sickness. This disease, which lacks effective treatments, affects millions of humans and livestock in sub-Saharan Africa. This paper reveals a mechanism by which the parasite can evade our immune response. Indolepyruvate is a metabolite produced by the parasite and it manipulates the immune cells, called macrophages, preventing them from becoming fully active. The selective...
Paper Details
Title
Trypanosoma bruceimetabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion
Published Date
Nov 15, 2016
Volume
113
Issue
48
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Notes
History