Sarah E. Corcoran
Trinity College, Dublin
Innate immune systemProinflammatory cytokineImmunologyBiologyImmune system
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Publications 6
#1James O Early (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2Deepthi MenonH-Index: 10
Last. Annie M. Curtis (RCSI: Royal College of Surgeons in Ireland)H-Index: 4
view all 18 authors...
A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a critical role in the innate immune system, limiting inflammation via reactive oxygen species (ROS) suppression and direct repression of the proinflammatory cytokines, IL-1β and IL-6. Here we reveal tha...
10 CitationsSource
#1Zbigniew Zasłona (Trinity College, Dublin)H-Index: 9
#2Eva M. Palsson-McDermott (Trinity College, Dublin)H-Index: 20
Last. Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
view all 9 authors...
PGE 2 has been shown to increase the transcription of pro–IL-1β. However, recently it has been demonstrated that PGE 2 can block the maturation of IL-1β by inhibiting the NLRP3 inflammasome in macrophages. These apparently conflicting results have led us to reexamine the effect of PGE 2 on IL-1β production. We have found that in murine bone marrow–derived macrophages, PGE 2 via the cAMP/protein kinase A pathway is potently inducing IL-1β transcription, as well as boosting the ability of LPS to i...
22 CitationsSource
#1Anne F. McGettrick (Trinity College, Dublin)H-Index: 18
#2Sarah E. Corcoran (Trinity College, Dublin)H-Index: 6
Last. Derek P. Nolan (Trinity College, Dublin)H-Index: 25
view all 13 authors...
Abstract The parasite Trypanasoma brucei causes African trypanosomiasis, known as sleeping sickness in humans and nagana in domestic animals. These diseases are a major burden in the 36 sub-Saharan African countries where the tsetse fly vector is endemic. Untreated trypanosomiasis is fatal and the current treatments are stage-dependent and can be problematic during the meningoencephalitic stage, where no new therapies have been developed in recent years and the current drugs have a low therapeut...
13 CitationsSource
Abstract HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably Il1b. The mechanism of LPS-stimulated HIF1α induction involves succinate, which inhibits prol...
72 CitationsSource
#1Clíona Ní Cheallaigh (Trinity College, Dublin)H-Index: 7
#2Frederick J. Sheedy (Trinity College, Dublin)H-Index: 19
Last. Joseph Keane (Trinity College, Dublin)H-Index: 35
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Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated p...
11 CitationsSource
#1Vincent Curtin (Trinity College, Dublin)H-Index: 3
#2Youness Amharar (Trinity College, Dublin)H-Index: 3
Last. Anne Marie Healy (Trinity College, Dublin)H-Index: 27
view all 7 authors...
Abstract The unintentional generation of amorphous character in crystalline active pharmaceutical ingredients (APIs) is an adverse consequence of mechanical activation during dosage form manufacture. In this study, we assess and compare the ability of low glass transition temperature ( T g ) dicarboxylic acids to mitigate amorphisation of a model API, salbutamol sulphate (SS), on both co-milling and co-mixing. SS processed alone, as well as co-milled and co-mixed composites of the API with gluta...
9 CitationsSource