Original paper
Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
Abstract
For more than half a century, genotoxic agents have been used to induce mutations in the genome of model organisms to establish genotype-phenotype relationships. While inaccurate replication across damaged bases can explain the formation of single nucleotide variants, it remained unknown how DNA damage induces more severe genomic alterations. Here, we demonstrate for two of the most widely used mutagens, i.e. ethyl methanesulfonate (EMS) and...
Paper Details
Title
Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
Published Date
Oct 18, 2016
Journal
Volume
12
Issue
10
Pages
e1006368 - e1006368
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Notes
History