Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Abstract
SF3b is a heptameric protein complex of the U2 small nuclear ribonucleoprotein (snRNP) that is essential for pre-mRNA splicing. Mutations in the largest SF3b subunit, SF3B1/SF3b155, are linked to cancer and lead to alternative branch site (BS) selection. Here we report the crystal structure of a human SF3b core complex, revealing how the distinctive conformation of SF3b155's HEAT domain is maintained by multiple contacts with SF3b130, SF3b10,...
Paper Details
Title
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Published Date
Oct 1, 2016
Journal
Volume
64
Issue
2
Pages
307 - 319
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