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Actions of Water Extract from Cordyceps militaris in Hyperuricemic Mice Induced by Potassium Oxonate Combined with Hypoxanthine.

Published on Dec 1, 2016in Journal of Ethnopharmacology3.41
· DOI :10.1016/j.jep.2016.10.001
Tianqiao Yong4
Estimated H-index: 4
,
Minglong Zhang1
Estimated H-index: 1
+ 6 AuthorsYizhen Xie4
Estimated H-index: 4
Cite
Abstract
Abstract Ethnopharmacological relevance Cordyceps militaris was recorded in the classic traditional Chinese medicine book with the main functions of “protecting liver and enhancing kidney functions”, influencing serum uric acid levels. Aim of study The aim is to investigate the hypouricemic effects and possible mechanism of C. militaris in hyperuricemic mice. Materials and methods A water extract (WECM) was prepared by decocting C. militaris directly at 80 °C in water bath, followed by lyophilization. WECM at 50, 100 and 200 mg/kg was orally administered to hyperuricemic mice induced by potassium oxonate and hypoxanthine combinedly and allopurinol (5 mg/kg) was served as a positive control. Results WECM exhibited excellent hypouricemic activity, which could decrease the serum uric acid levels of the hyperuricemic mice (306 μmol/L) to 189, 184 and 162 μmol/L at different doses respectively ( P P C. militaris were identified and their interaction energies with target were estimated between −200 and −400 kcal/mol. Conclusions These findings suggested that C. militaris produced significant hypouricemic actions and the hypouricemic effects of WECM may be attributed to the inhibitive effect of WECM on URAT1 protein levels. The results of blood urine nitrogen and serum creatinine levels and liver, kidney and spleen coefficients showed that WECM have no negative impacts on liver, renal and spleen functions. The screened four active compounds using molecular docking method deserve further investigation in other work.
  • References (44)
  • Citations (15)
Cite
References44
Newest
Published on Oct 23, 2015in PLOS Computational Biology
Armin Meier2
Estimated H-index: 2
(LMU: Ludwig Maximilian University of Munich),
Johannes Söding42
Estimated H-index: 42
(MPG: Max Planck Society)
Homology modeling predicts the 3D structure of a query protein based on the sequence alignment with one or more template proteins of known structure. Its great importance for biological research is owed to its speed, simplicity, reliability and wide applicability, covering more than half of the residues in protein sequence space. Although multiple templates have been shown to generally increase model quality over single templates, the information from multiple templates has so far been combined ...
Published on Dec 1, 2014in Current Microbiology1.59
Li Ma1
Estimated H-index: 1
(SCNU: South China Normal University),
Song Zhang1
Estimated H-index: 1
(SCNU: South China Normal University)
+ 1 AuthorsJianhua Gao1
Estimated H-index: 1
(SCNU: South China Normal University)
The hypouricemic actions of exopolysaccharide produced by Cordyceps militaris (EPCM) in potassium oxonate-induced hyperuricemia in mice were examined. Hyperuricemic mice were administered intragastrically with EPCM (200, 400 and 800 mg/kg body weight) or allopurinol (5 mg/kg body weight) once daily. Serum uric acid, blood urea nitrogen and liver xanthine oxidase (XOD) activities of each treatment were measured after administration for 7 days. EPCM showed dose-dependent uric acid-lowering actions...
Published on Sep 1, 2014in Carbohydrate Polymers6.04
Ding-Tao Wu14
Estimated H-index: 14
(UM: University of Macau),
Lan-Zhen Meng7
Estimated H-index: 7
(UM: University of Macau)
+ 6 AuthorsShao-Ping Li31
Estimated H-index: 31
(UM: University of Macau)
Abstract A polysaccharide, named as cordysinan, extracted from natural Cordyceps sinensis , was identified as a hyperbranched heteropolysaccharide from the results of FT-IR, GC–MS, and carbohydrate analysis by carbohydrate gel electrophoresis analysis, as well as the degree of branching of cordysinan was 43.3%. The solution properties of cordysinan were investigated by using size exclusion chromatography coupled with multi-angle laser light scattering and triple detector array, respectively. The...
Published on Sep 1, 2014in Separation and Purification Technology5.11
Ruizhan Chen5
Estimated H-index: 5
(Changchun Normal University),
Chenguang Jin4
Estimated H-index: 4
(Changchun Normal University)
+ 4 AuthorsSimin Yang2
Estimated H-index: 2
(Changchun Normal University)
Abstract Four polysaccharide fractions (CMP-1, CMP-2, CMP-3 and CMP-4) were extracted from cultured Cordyceps militaris (CM) using ultrahigh pressure extraction (UHPE), and purified using ultrafiltration, DEAE-Sepharose Fast Flow and Sephadex G-100 column chromatography. The effects on yields of crude polysaccharides (CCMP) were investigated by the response surface methodology (RSM) based on Box-Behnken Design (BBD). The optimal extraction condition for UHPE was: 5.18 min, 424 MPa, and 43.5 °C. ...
Published on Jul 1, 2014in International Journal of Oncology3.57
I. Made Winarsa Ruma6
Estimated H-index: 6
(Okayama University),
Endy Widya Putranto7
Estimated H-index: 7
(Okayama University)
+ 8 AuthorsHitoshi Murata15
Estimated H-index: 15
(Okayama University)
Angiogenesis is essential for tumor development and metastasis. Among several angiogenic factors, vascular endothelial growth factor receptor (VEGF) is important for tumor-derived angiogenesis and commonly overexpressed in solid tumors. Thus, many antitumor strategies targeting VEGF have been developed to inhibit cancer angiogenesis, offering insights into the successful treatment of solid cancers. However, there are a number of issues such as harmful effects on normal vascularity in clinical tr...
Published on May 31, 2014in Biomolecules & Therapeutics3.09
Dong-Ha Lee8
Estimated H-index: 8
(Inje University),
Hyun-Hong Kim6
Estimated H-index: 6
(Inje University)
+ 5 AuthorsHwa-Jin Park14
Estimated H-index: 14
(Inje University)
In this study, we prepared cordycepin-enriched (CE)-WIB801C, a n-butanol extract of Cordyceps militaris-hypha, and investigated the effect of CE-WIB801C on collagen-induced human platelet aggregation. CE-WIB801C dose-dependently inhibited collagen-induced platelet aggregation, and its IC50 value was 175 μg/ml. CE-WIB801C increased cAMP level more than cGMP level, but inhibited collagen-elevated [Ca2+]i mobilization and thromboxane A2 (TXA2) production. cAMP-dependent protein kinase (A-kinase) in...
Published on May 1, 2014in Fish & Shellfish Immunology3.30
Hong-Joo Joung2
Estimated H-index: 2
(Konkuk University),
Yon-Suk Kim15
Estimated H-index: 15
(Konkuk University)
+ 6 AuthorsPyo-Jam Park33
Estimated H-index: 33
(Konkuk University)
Abstract In this study, Haliotis discus hannai ( H. discus hannai ) fermentation was attempted with Cordyceps militaris ( C. militaris ) mycelia using a solid culture. We tried to ferment H. discus hannai to determine the optimal conditions fermentation with regards to its anti-inflammatory effects. The extracts of H. discu s hannai fermented with C. militaris mycelia (HFCM-5) showed higher nitric oxide inhibitory effects than H. discus hannai and C. militaris alone. HFCM-5 also decreased pro-in...
Published on May 1, 2014in Biochemical and Biophysical Research Communications2.71
Youki Ueda5
Estimated H-index: 5
(Okayama University),
Kyoko Mori11
Estimated H-index: 11
(Okayama University)
+ 3 AuthorsNobuyuki Kato49
Estimated H-index: 49
(Okayama University)
Abstract Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. Although the sustained virologic response rate in the treatment of genotype 1 using new triple therapy (pegylated-interferon, ribavirin, and telaprevir/boceprevir) has been improved by more than 70%, several severe side effects such as skin rash/ageusia and advanced anemia have become a problem. Under these circumstances, a new type of anti-HCV oral drug with few side effects is ne...
Published on May 1, 2014in Acta Pharmacologica Sinica4.01
Xia Liu2
Estimated H-index: 2
,
Fang Zhong4
Estimated H-index: 4
+ 10 AuthorsYing Lu2
Estimated H-index: 2
Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis
Published on Jan 1, 2014in International Journal of Rheumatology
Valderílio Feijó Azevedo15
Estimated H-index: 15
,
Pedro Grachinski Buiar3
Estimated H-index: 3
+ 2 AuthorsMauricio Carvalho1
Estimated H-index: 1
Objective. To profile a sample of gouty patients treated with allopurinol, benzbromarone, or a combination of these two drugs and to describe the impact of this therapy in reducing uric acid levels. Methods. An observational, transversal study was performed. We evaluated 48 patients diagnosed with gout who were seen at the Outpatient Rheumatology Clinic of the Federal University of Parana between January 2009 and November 2010. Clinical data, creatinine serum levels, and basal and posttreatment ...
Cited By15
Newest
Published on May 22, 2019in Nature Reviews Rheumatology18.55
Jie Lu (University of Otago), Nicola Dalbeth44
Estimated H-index: 44
(University of Auckland)
+ 3 AuthorsWenhua Wei14
Estimated H-index: 14
(University of Otago)
Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates, including in humans, because of inactivation of the gene encoding uricase during primate evolution. Individuals with hyperuricaemia might develop gout — a painful inflammatory arthritis caused by monosodium urate crystal deposition in articular structures. Hyperuricaemia is also associated with common chronic diseases, including hypertension, chronic kidney disease, type 2 diabetes and cardiovascular disease. ...
Published on May 16, 2019in Archives of Physiology and Biochemistry2.11
Walid Hamdy El-Tantawy2
Estimated H-index: 2
AbstractHyperuricaemia is characterised by a high level of urate in the blood. The crystallisation of urate is considered a critical risk factor for the development of gout. Allopurinol and febuxostat have been commonly used medications to decrease the circulating urate levels. However, the use of these drugs is associated with undesired side effects. Therefore, the development of a new active, safety anti-hyperuricaemic and anti-inflammatory drug could be useful in gout therapy and is highly ju...
Published on Jan 29, 2019in Medicines
Tran Ngoc Quy1
Estimated H-index: 1
,
Tran Dang Xuan25
Estimated H-index: 25
Background: Cordyceps militaris is a medicinal mushroom and has been extensively used as a folk medicine in East Asia. In this study, the separation of constituents involved in xanthine oxidase (XO) inhibitory, antioxidant and antibacterial properties of C. militaris was conducted. Methods: The aqueous residue of this fungus was extracted by methanol and then subsequently fractionated by hexane, chloroform, ethyl acetate and water. The ethyl acetate extract possessed the highest XO inhibitory an...
Published on Jan 1, 2019in Pharmaceutical Biology2.49
Cong Fang (JUTCM: Jiangxi University of Traditional Chinese Medicine), Lanying Chen (JUTCM: Jiangxi University of Traditional Chinese Medicine)+ 6 AuthorsYongyan Xie (JUTCM: Jiangxi University of Traditional Chinese Medicine)
AbstractContext: Eucommia ulmoides Oliver (Eucommiaceae) has various medicinal properties. Our previous studies revealed that Eucommia ulmoides has a protective effect on hyperuricaemia.Objective: This study investigates the effect of Eucommia ulmoides cortex ethanol extract (EU) on hyperuricaemia and explores the underlying mechanism in Kunming mice and Sprague–Dawley rats.Material and methods: Sixty mice and sixty rats were divided into normal control, hyperuricaemia, allopurinol (10 mg/kg) an...
Published on Jan 1, 2019in Food & Function3.24
Xiaoyun Qian1
Estimated H-index: 1
(SYSU: Sun Yat-sen University),
Xu Wang1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
+ 7 AuthorsWenhua Ling36
Estimated H-index: 36
(SYSU: Sun Yat-sen University)
Hyperuricemia (HUA) is a universal metabolic disorder characterized by a high level of uric acid in the serum. Anthocyanins (ACNs) are a group of natural flavonoids that have shown favourable bioactivities in the metabolic syndrome but the effect on uric acid metabolism remains underexplored. The present study investigated the hypouricemic effects of ACNs in a mice model and further studied the potential mechanisms. ICR mice based on a high-yeast diet were administered potassium oxonate (PO, 280...
Published on Oct 18, 2018in International Journal of Molecular Sciences4.18
Tianqiao Yong4
Estimated H-index: 4
,
Shaodan Chen4
Estimated H-index: 4
+ 7 AuthorsDiling Chen3
Estimated H-index: 3
Inonotus obliquus is an edible mushroom and also a remedy against various diseases, especially metabolic syndrome. In this paper we report the actions of an ethanol extract of I. obliquus (IOE) against hyperuricemia in hyperuricemic mice, and the screen of bioactives. The extract (IOE) was prepared by extracting I. obliquus at 65 °C with ethanol, and characterized by HPLC. IOE at low, middle, and high doses reduced serum uric acid (SUA) of hyperuricemic mice (353 μmol/L) to 215, 174, and 152 μmo...
Published on Sep 28, 2018in Nutrients4.17
Young-Sil Lee2
Estimated H-index: 2
,
Hak Jae Kim106
Estimated H-index: 106
+ 1 AuthorsK Dong-Seon9
Estimated H-index: 9
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal ur...
Published on Sep 1, 2018in Fitoterapia2.43
Opeyemi Joshua Olatunji3
Estimated H-index: 3
(PSU: Prince of Songkla University),
Jian Tang4
Estimated H-index: 4
(Jiangsu University)
+ 3 AuthorsZhen Ouyang5
Estimated H-index: 5
(Jiangsu University)
Abstract The genus Cordyceps has about 750 identified species which are distributed in many regions of the World, but mainly found in South Asia, Europe and North America. The species of the genus are highly priced and are widely used as food and medicine for the treatment of various ailments. This present review compiles literature information on the ethno-medicinal, phytochemistry and pharmacological properties of species in the genus Cordycep s. In addition, the review also suggest recommenda...
Published on May 7, 2018in International Journal of Molecular Sciences4.18
Danling Liang1
Estimated H-index: 1
,
Tianqiao Yong4
Estimated H-index: 4
+ 7 AuthorsDan Zuo1
Estimated H-index: 1
Searching novel hypouricemic agents of high efficacy and safety has attracted a great attention. Previously, we reported the hypouricemic effect of Ganoderma applanatum, but its bioactives, was not referred. Herein, we report the hypouricemic effect of 2,5-dihydroxyacetophenone (DHAP), a compound screened from Ganoderma applanatum computationally. Serum parameters, such as uric acid (SUA), xanthine oxidase (XOD) activity, blood urea nitrogen (BUN), and creatinine were recorded. Real-time reverse...
Published on Apr 1, 2018in Journal of Functional Foods3.20
Shaodan Chen4
Estimated H-index: 4
,
Tianqiao Yong4
Estimated H-index: 4
+ 4 AuthorsYizhen Xie2
Estimated H-index: 2
Abstract Previously, polysaccharides with hypoglycemic effects from G. frondosa were reported by us. To explore compounds against α-glucosidase and human tumor cells, three extractive fractions (GF-1–GF-3) were prepared from G. frondosa ethanol extraction (GF) by chromatographic column. Rather than GF-1 and GF-2, the fraction GF-3 demonstrated inhibitory actions against α-glucosidase and proliferation of human tumor cells dominantly. To identify the bioactive compounds in GF-3, one new compound ...