Original paper
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
Abstract
Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, β-amyloid 1–42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight...
Paper Details
Title
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
Published Date
Jan 1, 2017
Journal
Volume
49
Pages
138 - 144
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Notes
History