Editing DNA Methylation in the Mammalian Genome
Abstract
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene expression networks in many biological processes. However, investigation of the functions of specific methylation events remains challenging. Here, we demonstrate that fusion of Tet1 or Dnmt3a with a catalytically inactive Cas9 (dCas9) enables targeted DNA methylation editing. Targeting of the dCas9-Tet1 or -Dnmt3a fusion protein to methylated or unmethylated...
Paper Details
Title
Editing DNA Methylation in the Mammalian Genome
Published Date
Sep 1, 2016
Journal
Volume
167
Issue
1
Pages
233 - 247.e17
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