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Rudolf Jaenisch
Massachusetts Institute of Technology
Embryonic stem cellMolecular biologyGeneticsBiologyCell biology
503Publications
145H-index
87.8kCitations
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Publications 483
Newest
#1Nobuhito Murai (MIT: Massachusetts Institute of Technology)
#2Maisam Mitalipova (MIT: Massachusetts Institute of Technology)H-Index: 13
Last. Rudolf Jaenisch (MIT: Massachusetts Institute of Technology)H-Index: 145
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Microglia are the primary immune cells of the central nervous system and crucial to proper development and maintenance of the brain. Microglia have been recognized to be associated with neurodegenerative diseases and neuroinflammatory disorders. CX3C chemokine receptor 1 (CX3CR1), which is specifically expressed in microglia, regulates microglia homeostatic functions such as microglial activation and is downregulated in aged brain and disease associated microglia in rodents, yet its role in huma...
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#2Maisam MitalipovaH-Index: 13
Last. Rudolf JaenischH-Index: 145
view all 3 authors...
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#1Clara Dees (FAU: University of Erlangen-Nuremberg)H-Index: 34
#2Sebastian Pötter (FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Kolja Gelse (FAU: University of Erlangen-Nuremberg)H-Index: 32
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Fibroblasts are key-effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation maybe initiated by external factors, prolonged activation can induce an "autonomous", self-maintaining pro-fibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role to establish this persistently activated pathologic phenotype of fibrobla...
1 CitationsSource
#1X. Shawn Liu (Columbia University)H-Index: 1
#1X. Shawn Liu (Columbia University)H-Index: 14
Last. Rudolf Jaenisch (MIT: Massachusetts Institute of Technology)H-Index: 145
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Genetic studies of epigenetic modifiers such as DNA methyltransferases and histone acetyltransferases have revealed a critical role for epigenetic regulation during brain development and function. Alteration of epigenetic modifications have been documented in a variety of brain disorders, including neurodevelopmental, psychiatric, and neurodegenerative diseases. Development of epigenome editing tools enables a functional dissection of the link between altered epigenetic changes and disease outco...
3 CitationsSource
#1John D. GraefH-Index: 6
#2Hao WuH-Index: 83
Last. Owen WallaceH-Index: 1
view all 11 authors...
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#1Karen E. Ocwieja (Boston Children's Hospital)H-Index: 1
#2Alexandra Stanton (Harvard University)
Last. Lee Gehrke (MIT: Massachusetts Institute of Technology)H-Index: 33
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Background The molecular mechanisms underpinning the neurologic and congenital pathologies caused by Zika virus (ZIKV) infection remain poorly understood. One barrier has been the lack of relevant model systems for the developing human brain; however, thanks to advances in the stem cell field, we can now evaluate ZIKV central nervous system infections in human stem cell-derived cerebral organoids which recapitulate complex 3-dimensional neural architecture.
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#1Xin Tang (MIT: Massachusetts Institute of Technology)H-Index: 8
#2Jesse Drotar (MIT: Massachusetts Institute of Technology)H-Index: 3
Last. Rudolf Jaenisch (MIT: Massachusetts Institute of Technology)H-Index: 145
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Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl CpG binding protein 2 (MECP2) gene. There are currently no approved treatments for RTT. The expression of K+/Cl− cotransporter 2 (KCC2), a neuron-specific protein, has been found to be reduced in human RTT neurons and in RTT mouse models, suggesting that KCC2 might play a role in the pathophysiology of RTT. To develop neuron-based high-throughput screening (HTS) assays to identify chemical compounds that enhan...
18 CitationsSource
#1Julien Pontis (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 2
#1Julien Pontis (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 13
Last. Didier Trono (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 87
view all 9 authors...
Summary Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcriptional regulators, thus enabling coordinated genome-wide activation of species- and context-specific gene expression programs, but such regulation must be balanced against their genotoxic potential. Here, we show that Kruppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) control the timely and pleiotropic activation of TE-derived...
44 CitationsSource
#1Malkiel A. Cohen (MIT: Massachusetts Institute of Technology)H-Index: 14
#2Shupei Zhang (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Rudolf Jaenisch (MIT: Massachusetts Institute of Technology)H-Index: 145
view all 9 authors...
Neuroblastoma (NB), derived from the neural crest (NC), is the most common pediatric extracranial solid tumor. Here we establish a platform that allows studying human NBs in mouse-human NC chimeras. Chimeric mice were produced by injecting human NC cells carrying NB relevant oncogenes in-utero into gastrulating mouse embryos. The mice developed tumors composed of a heterogenous cell population that closely resembled that seen in primary NBs of patients but were significantly different from homog...
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#1Attya Omer Javed (MIT: Massachusetts Institute of Technology)H-Index: 2
#2Yun Li (MIT: Massachusetts Institute of Technology)H-Index: 14
Last. Rudolf Jaenisch (MIT: Massachusetts Institute of Technology)H-Index: 145
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Summary Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro differentiation of human embryonic stem cells to monitor the effect of a point mutation in kinetochore null protein 1 (KNL1; CASC5), identified in microcephaly patients, during in vitro brain development. We found that neural progenitors bearing a patie...
11 CitationsSource
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