Review paper
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
Abstract
Advances in the development of delivery, repair, and specificity strategies for the CRISPR-Cas9 genome engineering toolbox are helping researchers understand gene function with unprecedented precision and sensitivity. CRISPR-Cas9 also holds enormous therapeutic potential for the treatment of genetic disorders by directly correcting disease-causing mutations. Although the Cas9 protein has been shown to bind and cleave DNA at off-target sites, the...
Paper Details
Title
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
Published Date
Aug 1, 2016
Journal
Volume
63
Issue
3
Pages
355 - 370
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