ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
Abstract
Lipid accumulation in macrophages has profound effects on macrophage gene expression and contributes to the development of atherosclerosis. Here, we report that angiopoietin-like protein 4 (ANGPTL4) is the most highly upregulated gene in foamy macrophages and it's absence in haematopoietic cells results in larger atherosclerotic plaques, characterized by bigger necrotic core areas and increased macrophage apoptosis. Furthermore, hyperlipidemic...
Paper Details
Title
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
Published Date
Jul 27, 2016
Journal
Volume
7
Issue
1
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