Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Association of Specific Dietary Fats With Total and Cause-Specific Mortality

Published on Aug 1, 2016in JAMA Internal Medicine 19.99
· DOI :10.1001/jamainternmed.2016.2417
Dong D. Wang19
Estimated H-index: 19
(Harvard University),
Yanping Li43
Estimated H-index: 43
(Harvard University)
+ 5 AuthorsFrank B. Hu202
Estimated H-index: 202
(Harvard University)
Abstract
Importance Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent. Objective To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies. Design, Setting, and Participants This cohort study investigated 83 349 women from the Nurses’ Health Study (July 1, 1980, to June 30, 2012) and 42 884 men from the Health Professionals Follow-up Study (February 1, 1986, to January 31, 2012) who were free of cardiovascular disease, cancer, and types 1 and 2 diabetes at baseline. Dietary fat intake was assessed at baseline and updated every 2 to 4 years. Information on mortality was obtained from systematic searches of the vital records of states and the National Death Index, supplemented by reports from family members or postal authorities. Data were analyzed from September 18, 2014, to March 27, 2016. Main Outcomes and Measures Total and cause-specific mortality. Results During 3 439 954 person-years of follow-up, 33 304 deaths were documented. After adjustment for known and suspected risk factors, dietary total fat compared with total carbohydrates was inversely associated with total mortality (hazard ratio [HR] comparing extreme quintiles, 0.84; 95% CI, 0.81-0.88; P trans -fat ( P P P  = .002 for trend). Conclusions and Relevance Different types of dietary fats have divergent associations with total and cause-specific mortality. These findings support current dietary recommendations to replace saturated fat and trans -fat with unsaturated fats.
  • References (46)
  • Citations (117)
Cite
References46
Newest
Published on Oct 1, 2015in Journal of the American College of Cardiology 16.83
Yanping Li43
Estimated H-index: 43
(Harvard University),
Adela Hruby18
Estimated H-index: 18
(Harvard University)
+ 8 AuthorsBarry M. Popkin319
Estimated H-index: 319
(Harvard University)
Abstract Background The associations between dietary saturated fats and the risk of coronary heart disease (CHD) remain controversial, but few studies have compared saturated with unsaturated fats and sources of carbohydrates in relation to CHD risk. Objectives This study sought to investigate associations of saturated fats compared with unsaturated fats and different sources of carbohydrates in relation to CHD risk. Methods We followed 84,628 women (Nurses’ Health Study, 1980 to 2010), and 42,9...
138 Citations Source Cite
Published on Aug 11, 2015in BMJ 23.56
Russell J. de Souza35
Estimated H-index: 35
,
Andrew Mente30
Estimated H-index: 30
(McMaster University)
+ 8 AuthorsJoseph Beyene61
Estimated H-index: 61
(McMaster University)
Objective To systematically review associations between intake of saturated fat and trans unsaturated fat and all cause mortality, cardiovascular disease (CVD) and associated mortality, coronary heart disease (CHD) and associated mortality, ischemic stroke, and type 2 diabetes. Design Systematic review and meta-analysis. Data sources Medline, Embase, Cochrane Central Registry of Controlled Trials, Evidence-Based Medicine Reviews, and CINAHL from inception to 1 May 2015, supplemented by bibliogra...
336 Citations Source Cite
Published on Dec 1, 2014in Arteriosclerosis, Thrombosis, and Vascular Biology 6.09
Jyrki K. Virtanen28
Estimated H-index: 28
(University of Eastern Finland),
Jaakko Mursu31
Estimated H-index: 31
(University of Eastern Finland)
+ 1 AuthorsSari Voutilainen40
Estimated H-index: 40
(University of Eastern Finland)
Objective— The epidemiological evidence of the role of dietary saturated fatty acids (SFA) in the development of coronary heart disease (CHD) is inconsistent. We investigated the associations of dietary fatty acids with the risk of CHD and carotid atherosclerosis in men with high SFA intake and high rates of CHD. Approach and Results— In total, 1981 men from the population-based Kuopio Ischemic Heart Disease Risk Factor Study (KIHD), aged 42 to 60 years and free of CHD at baseline in 1984 to 198...
26 Citations Source Cite
Published on Oct 28, 2014in Circulation 18.88
William S. Harris74
Estimated H-index: 74
(USD: University of South Dakota),
Gregory C. Shearer17
Estimated H-index: 17
(PSU: Pennsylvania State University)
The once-settled roles of all dietary fatty acid classes vis-a-vis coronary heart disease (CHD) seem to be under fire these days. For decades it had been received wisdom that "saturated fats are bad," and that margarines should replace butter to reduce risk for heart attacks. But a recent Time magazine cover that screamed, "EAT BUTTER" illustrates this changing perspective1. Olive oil, the poster child of the "Mediterranean Diet" and a rich source of oleic acid, has long been nearly worshiped as...
32 Citations Source Cite
Published on Oct 28, 2014in Circulation 18.88
Maryam Sadat Farvid1
Estimated H-index: 1
(Shahid Beheshti University of Medical Sciences and Health Services),
Ming Ding10
Estimated H-index: 10
(Harvard University)
+ 5 AuthorsFrank B. Hu202
Estimated H-index: 202
(Harvard University)
Background—Previous studies on intake of linoleic acid (LA), the predominant n-6 fatty acid, and coronary heart disease (CHD) risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of dietary LA intake and CHD risk. Methods and Results—We searched MEDLINE and EMBASE databases through June 2013 for prospective cohort studies that reported the association between dietary LA and CHD ...
179 Citations Source Cite
Published on Oct 7, 2014in Circulation 18.88
Jason H.Y. Wu33
Estimated H-index: 33
(The George Institute for Global Health),
Rozenn N. Lemaitre2
Estimated H-index: 2
(UW: University of Washington)
+ 4 AuthorsDariush Mozaffarian113
Estimated H-index: 113
(Tufts University)
Background —While omega-6 polyunsaturated fatty acids(n-6 PUFA) have been recommended to reduce CHD, controversy remains about benefits vs. harms, including concerns over theorized pro-inflammatory effects of n-6 PUFA. We investigated associations of circulating n-6 PUFA including linoleic acid(LA, the major dietary PUFA), γ-linolenic acid(GLA), dihomo-γ-linolenic acid(DGLA), and arachidonic acid(AA),with total and cause-specific mortality in the Cardiovascular Health Study, a community-based US...
76 Citations Source Cite
Published on Sep 16, 2014in Annals of Internal Medicine 19.38
Barry M. Popkin319
Estimated H-index: 319
(Harvard University),
Meir J. Stampfer247
Estimated H-index: 247
(Harvard University),
Frank M. Sacks109
Estimated H-index: 109
(Harvard University)
TO THE EDITOR: We appreciate that Chowdhury and colleagues (1) have corrected some of the gross errors in their original paper. Of note, the inverse association of intake of long-chain -3 polyunsaturated fatty acids (PUFAs) with cardiovascular disease (CVD) risk is now significant. We also appreciate the sensitivity analysis showing that with exclusion of the outlying SDHS (Sydney Diet Heart Study), the included randomized, controlled trials (RCTs) show benefit of replacing saturated fatty acids...
7 Citations Source Cite
Published on Sep 1, 2014in JAMA Neurology 11.46
Kathryn C. Fitzgerald13
Estimated H-index: 13
(Harvard University),
Éilis J. O’Reilly16
Estimated H-index: 16
(Harvard University)
+ 4 AuthorsAlberto Ascherio116
Estimated H-index: 116
(Harvard University)
RESULTS A total of 995 ALS cases were documented during the follow-up. A greater ω-3 PUFA intake was associated with a reduced risk for ALS. The pooled, multivariable-adjusted RR for the highest to the lowest quintile was 0.66 (95% CI, 0.53-0.81; P < .001 for trend). Consumption of both α-linolenic acid (RR, 0.73; 95% CI, 0.59-0.89; P = .003 for trend) and marine ω-3 PUFAs (RR, 0.84; 95% CI, 0.65-1.08; P = .03 for trend) contributed to this inverse association. Intakes of ω-6 PUFA were not assoc...
47 Citations Source Cite
Published on Mar 18, 2014in Annals of Internal Medicine 19.38
Rajiv Chowdhury47
Estimated H-index: 47
,
Samantha Warnakula9
Estimated H-index: 9
+ 11 AuthorsSimon G. Thompson95
Estimated H-index: 95
Primary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
606 Citations Source Cite
Published on Mar 15, 2014in American Journal of Epidemiology 4.32
Griffith A. Bell1
Estimated H-index: 1
(Fred Hutchinson Cancer Research Center),
Elizabeth D. Kantor15
Estimated H-index: 15
(Fred Hutchinson Cancer Research Center)
+ 3 AuthorsEmily White51
Estimated H-index: 51
(Fred Hutchinson Cancer Research Center)
Evidence from experimental studies suggests that the long-chain ω-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid have beneficial effects that may lead to reduced mortality from chronic diseases, but epidemiologic evidence is mixed. Our objective was to evaluate whether intake of long-chain ω-3 fatty acids from diet and supplements is associated with cause-specific and total mortality. Study participants (n= 70,495) were members of a cohort study (the Vitamins and Lifestyle Study) w...
32 Citations Source Cite
Cited By117
Newest
Published on Apr 6, 2019in Lipids in Health and Disease 2.66
Yongjian Zhu (Zhengzhou University), Yacong Bo (Zhengzhou University), Yanhua Liu (Zhengzhou University)
Background Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be more credible.
Source Cite
Published on May 1, 2019in Prostate Cancer and Prostatic Diseases 4.10
Michael A. Liss24
Estimated H-index: 24
(University of Texas at Austin),
Osamah Al-Bayati (University of Texas at Austin)+ 9 AuthorsBrandi Weaver (University of Texas at Austin)
To study the association of nutrient intake measured by baseline food frequency questionnaire and risk of subsequent prostate cancer (PCa) in the SABOR (San Antonio Biomarkers of Risk) cohort study. After IRB approval, more than 1903 men enrolled in a prospective cohort from 2000 to 2010 as part of the SABOR clinical validation site for the National Cancer Institute Early Detection Research Network. Food and nutrient intakes were calculated using a Food Frequency Questionnaire. Cox proportional ...
Source Cite
Published on May 1, 2019in Current Atherosclerosis Reports 2.56
Elena Hemler1
Estimated H-index: 1
(Harvard University),
Frank B. Hu202
Estimated H-index: 202
(Harvard University)
Purpose of Review Plant-based diets have been widely promoted for cardiovascular disease (CVD) risk reduction. This review discusses the various definitions of plant-based diets and summarizes their associations with CVD risk, specifically distinguishing between healthy and unhealthy plant-based diets.
Source Cite
Published on Apr 12, 2019in Circulation Research 15.21
Marta Guasch-Ferré20
Estimated H-index: 20
(Harvard University),
Geng Zong16
Estimated H-index: 16
(CAS: Chinese Academy of Sciences)
+ 4 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Rationale: Dietary monounsaturated fatty acids (MUFAs) can come from both plant and animal sources with divergent nutrient profiles that may potentially obscure the associations of total MUFAs with chronic diseases. Objective: To investigate the associations of cis-MUFA intake from plant (MUFA-P) and animal (MUFA-A) sources with total and cause-specific mortality. Methods and Results: We followed 63,412 women from the Nurses' Health Study (1990-2012) and 29,966 men from the Health Professionals ...
1 Citations Source Cite